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It certainly is and I appreciate the impossibility of your situation. However, I would query whether one should take too much notice of what Melvin Ramsay said. When I look this account I get the impression that he was not a very rigorous observer. He is popular because his name is associated...

It certainly is and I appreciate the impossibility of your situation. However, I would query whether one should take too much notice of what Melvin Ramsay said. When I look this account I get the impression that he was not a very rigorous observer. He is popular because his name is associated...

It almost certainly has to do with sites of tensile force in continuous postural muscle action. Most muscles in the body are called on to do specific jobs intermittently. But trapezius and soleus (which is in the same place as gastrocnemius) contract almost constantly just to keep your body...

It may be like insulin and diabetes but whatever it is does not look likely to be something like lactate. And the problem is not so much that findings are inconsistent. As far as I know measurements are just normal. Maybe finding it impossible to do any significant activity, feeling ill, and...

The problem is we have no idea.

It does not really get to the meat of the matter for me. The sentence: Such a public spat however, is unlikely to be good for science or evidence-based medicine, and indeed may have some wider implications for some fundamentals of science and science communication... seems to me wrong. It is...

I usually go by abstracts. But if an abstract 'spins' in the sense of coming to a conclusion that is not already evident from the data presented then for me it is heavily marked down, or very likely binned. Good scientific studies are not hard to assess from an abstract. The conclusion is not...

I think definitely not. Foci of tenderness in muscles occur normally anyway, unrelated to activity, particularly in the trapezius. I think this is a bit like the tender points of fibromyalgia - it does not mean anything useful. These are just the points that tend to be tender in everyone. I...

You don't really need to worry. The only things that citation number really matters for is promotion and tenure. These people are all professors already and mostly retiring.

The poor man is trying to explain to himself what he ought to be thinking. Perhaps he should realise that no explanation of this sort is needed. cytokines make you feel yuk - that is all we need to know.

No it is a different substance altogether. One is alpha and one is beta.

NICE gathers all relevant publications but that is different from a meta-analysis. Inmost cases you look at the publications and if there is solid evidence from any of them that is enough. Most drug regulatory authorities require more than one study showing efficacy but NICE has on occasion...

If I remember rightly you feel terrible with hours of the interferon injection. It is likely that you have had the hepatitis for years at that point.

I think NICE have their own reviewing procedure. That probably includes picking up what Cochrane has done. I have no heard of NICE getting reviews done by others but it is possible.

It is based on things he has said in the past and in particular on a referee's report he wrote on someone else's paper that became public. He basically said that any paper that did not say that ME was biopsychosocial had to be rewritten (he considered that non-negotiable). He might have changed...

I agree that not very much insight seems to have emerged from the studies themselves relating to mechanism. The interferon does not hang around long. I do not think there is any doubt that it is the interferon rather than the virus that causes the fatigue or that the fatigue goes on far longer...

I agree. I think there is avery important message in the alpha interferon story - that fatigue can persist long after the triggering signal has gone. Some other signal must then take over. Moreover, there is no need for any specific autoimmune response. The pity is that Pariente is still as far...

So who tweets for AfME and is happy to quote 'classic psychosocial factors' as if it meant anything?

I think that broader perspective is very useful. Basically, meta-analyses were never very powerful. They are now probably completely misused and useless. If you think about it, if individual studies are good enough there should be no need for any meta-analysis. And in the great majority of...

But the point is that it is used for people who are already live zombies, like my wife. I am glad to have her back alive and well. Your argument seems to me to be based on emotion and hearsay rather than what is good for people. The stuff about burning out bran is nonsense. The ECT practitioners...