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The problem is that they are comparing apples with oranges. The ramping and encouragement matters a great deal if they claim to be measuring maximal exertion. The "hyperventilation" group did not have the same effect on performance as the SOEL and SOEH groups and the SOE groups were split 50/50...

Notably, 185 of the 257 patients were excluded due to high blood pressure or heart failure... The hyperventilation explanation doesn't make much sense to me, I'm wondering if there is a bit of Pulmonologist bias? When you're a hammer, everything looks like a nail... They noted the following of...

*cough* unrandomised.

Quantum fatigue sounds so sciencey!

¯\_(ツ)_/¯

It is important to point out that there is a big difference between correlations at a static point in time and correlations in an unblinded prospective clinical trial which is inherently subject to various biases.

How yer doing? (visual analogue) is more relevant and understandable than the Chalder Fatigue Scale. ;)

This is what came to mind when you said that: (sorry for offtopic)

Numbness of the face is not a symptom of ME or CFS.

I don't really see the big deal, I mean if stress is part of the pathology and the drug works, then fantastic. But we also need to emphasise the reverse, namely if the drug doesn't work, then we need to abandon hypotheses that involve the corticotropin-releasing factor (and glucocorticoid...

It's an interesting test, but motivation is still a factor, so it's relevance for testing the outcome of GET is not clear cut.

Because patients don't know anything about methodological biases. We're just here to be experimented on!

What are the laws in Australia. I know it is not legal to record private conversations in South Australia without the permission of both parties. Kind of nonsense that it's called a wiretap law when no actual phones are involved though...

Or it just represents questionnaire answering bias because the study was not blinded....

Quantifying the circular reasoning Between Psychotherapy Content and Clinical Outcomes Using Deep Learning. ;)

Eight 2 day CPET studies published so far, perhaps this will be the 9th? :woot:

PEM is not DOMS, it's frustrating when doctors don't listen to patients and then insist on their own (wrong) ideas.

Maybe you should go on holiday?

For two and a half months? Sounds like my perfect job!