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Highlights 20 patients with persistent neuromuscular symptoms including fatigue, 77–255 (median: 216) days after acute COVID-19 were examined. Nerve oncduction studies did not show signs of neuropathy but 11 patients (55%) had myopathic changes with quantitative electromyography. Myopathy may...

I think that protocol probably can be either of those things, depending on the situation and clinician. I can imagine that there are times when it is a reasonable approach. What if a dietician is talking to a person who eats mostly crisps and hot chips, and drinks only energy drinks? I still...

But that wasn't the point he was making there in those paragraphs. If he had tackled that issue, it would have taken the piece off-topic. I think we'd need to see a lot more convincing evidence to conclude that Charles believes in somatisation. And then, my point was, so what if he does? A...

Very well said @Lou B Lou. There's a lot of misinformation about. Even resources that many people would think are useful have problems (for example the StudyPRN course that Nina Muirhead co-authored). The conferences from international organisations such as IACFS/ME; the presentations of the...

That's a good analysis. Here's the Discussion: I don't feel quite so negative towards microRNAs as potential biomarkers though. I'd like to see more work done on them in studies with carefully selected patients (i.e. not using a Fukuda criteria). The technology is there, so some more work...

This is a good question (N presumably being the nucleocapsid protein). How does the virus (any virus) hide in a cell but also cause a reaction major enough to cause ME/CFS? Perhaps the answer isn't that the impact of the virus is conventionally pro-inflammatory, as the authors suggest here. A...

obliterate? from Latin obliteratus, past participle of obliterare "cause to disappear, blot out (a writing), erase, efface," figuratively "cause to be forgotten, blot out a remembrance"

Thread on the paper here: The immunology of long COVID, 2023, Altmann et al

Here's the relevant bit. Italics are in the original. "A second trial carried out in Oxford (reference 455) divided a group of 60 ME/CFS patients into 30 receivingCBT and 30 who were given 'no further explanation or advice' about their illness - apart from being advised to increase their level...

Can you quote the section you mean DD? I'm not sure which bit to look at. Edit - sorry, just seen the page number

I certainly wish the conference had more Daniel and less oxaloacetate.

:) I want to make a joke about that horse now being unstable... (This is when we need Graham and a punny limerick.)

Great comment @rvallee.

As a welcome change from BPS fibromyalgia research, there's this paper, with a result that goes against the "Exercise solves all problems" mantra from a Granada team: An umbrella review of randomized control trials on the effects of physical exercise on cognition 2023 Ciria et al

Wow. Even I find this a bit hard to believe, but of course the confounding effect of healthy people being a lot more likely to be able to do exercise (and healthy people being less likely to have diseases affecting brain function) must be a significant contributor to society's prevailing view...

Early-onset hereditary isolated non-neurogenic orthostatic hypotension in a Swedish family, 2023, Jan Fagius et al Swedish researchers looking in detail at a family with orthostatic intolerance

Jan Fagius, Joakim Klar & Niklas Dahl Uppsala University Looks as those these researchers might be interested in further work on this. I liked the careful way the researchers went about the investigation e.g.

Thanks MSEspe! Interesting to read those links. There's a huge Cochrane involvement, and, from Ecclestone, some extraordinary expressions of prejudice about CFS: Edit to add the thread on the source: Embodied: The psychology of physical sensation (2015) by C. Eccleston

On Amanda C de C Williams (the final author) an interview with transcript https://integrativepainscienceinstitute.com/latest_podcast/psychology-for-chronic-pain-does-it-help-with-dr-amanda-c-de-c-williams/