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A phase 2a open-label clinical trial to determine the effect of famciclovir on EBV activity as measured by EBV shedding in the saliva of patients with multiple sclerosis Abstract Background: Despite increasing evidence that Epstein–Barr virus (EBV) plays a causal role in MS, no treatments have...

Rob Wüst (Appelman et al) has said on Twitter that he can neither meaningfully interpret the study results (including the earlier ones of Scheibenbogen) nor that he is able to compare them to the results to his study. www.twitter.com/RobWust/status/1755111198096245100

A significant problem with this study could be that This algorithm is discussed here. It's currently established that Fluvoxamine does nothing for acute Covid-19 as there have been multiple RCTs on this subject, which is probably a good thing for their study as the severity confounder of the...

I'm afraid the problem with smart watches is that they are typically very inaccurate as they are lifestyle devices rather than anything else. Some of the fitness devices are better and are sometimes highly accurate in measuring certain things but completely inaccurate in measuring others. So if...

People have asked for further information. Thus far there haven't been responses that haven't been extremely vague. I believe this mainly has to do with this being run by patients who have no background in organising or attending scientific conferences and don't have a research background but...

Apart from showing strength in numbers does the petition have another value, as in a certain threshold of signatures crossed amounts to something? I was also wandering about the significance of the website petities.nl, is just a dutch version of something like change.org or or does it have more...

Can the Hospital Episode Statistics data be re-analysed to estimate the prevalence of different autoimmune diseases (or other conditions, Scheibenbogen claims Raynauds is more prevalent in ME/CFS patients) amongst those patients compared to the general population (a priori, to me, it might not...

I just saw another press release. I cannot judge the quality of their argument or how much of a problem it would be, but in this press release the authors propose that “Every cell in a woman’s body produces Xist. But for several decades, we’ve used a male cell line as the standard of reference...

I couldn't tell you as I don't have a medical background. All I can tell is that there seems to be a divide amongst autoimmunity researchers with one side of the group thinking "T-cells are everything" and many diseases, such as Type 1 Diabetes, Multiple Sclerosis, APSs, seemingly being widely...

Would that reasoning also apply to autoimmune diseases that many commonly classify as primarily T cell mediated?

The article is about this work Xist ribonucleoproteins promote female sex-biased autoimmunity. The paper hasn't been published yet, but will appear later today in Cell (the above preprint has been available for 1.5 years, so it's probably not spectular news for those working in this field).

I think the problem as Trish says is that we don't know anything about which disagreement this is referring to. Is it the useless and often typically attacking and harassing "LC vs ME" debate that has been constructed by some people on Twitter which you are refering to, is it the Dragons’ Den...

Haven’t looked into it, but from what you are saying it could indeed look interesting to me. It seems they “evaluate” many of the things that are also popular in ME/CFS communities (for example Fecal Transplants) so I a priori don’t think it should be an impossible task just because too little...

Artur Fedorowksi has replied to the response "Graded exercise therapy should not be recommended for patients with post-exertional malaise". I think this makes his position very clear. Of course he has no problem contradicting himself here since if there's no verdict he shouldn't have recommended...

There was a small RCT Fampridine for LC that was recently completed (results still outstanding). Fampridine is 4-Aminopyridine, whilst Amifampridine is 3,4-Diaminopyridine (not that I'd understand what that actually means but here are their chemical structures). It seems Fampridine was initially...

Reduced Fatigue Symptoms in the Post-COVID Syndrome With Amifampridine: A Collective Casuistry With Double-Blind Discontinuation Trials Abstract After a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, approximately 10-20% of patients are affected by the post-COVID...

Now published as Long COVID is associated with severe cognitive slowing: a multicentre cross-sectional study in the Lancet eClinicalMedicine.

Of course there will be differences I'm not able to comprehend, but at a first glance this essentially seems like a chinese version of Paxlovid, a 3CL inhibitor boosted by ritonavir (there's an abundance of other similar antivirals...

Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19 Abstract BACKGROUND Simnotrelvir is an oral 3-chymotrypsin–like protease inhibitor that has been found to have in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential efficacy in a...

This study should be interesting to anybody interested in viral persistence. I have wondered why the viral persistence researchers have largerly ignored immunocompromised patients for whom there is a lot of data that they can have a persistent infection for weeks or even months, but that there...