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Looks potentially important - the authors have a lot of impressive affiliations e.g. Yale School of Epidemiology. There is a risk that people who were experiencing persisting symptoms in the first weeks might have been more likely to sign up for inclusion in the study - there was that lag...

To be devil's advocate for a moment: Perhaps the BPS view does not require deconditioning to a level that is worse than healthy sedentary people? Perhaps it just requires a relative loss of fitness? So, for example, an elite athlete becomes sick and rests, abandoning training for a few weeks...

Ugh. Seems like they googled 'Long Covid treatments' and wrote about what they found in the mistaken belief that it was "knowledge". This is not science. Pragmatic = 'enables the doctor to sound as if they have something to offer, and keep charging you for the many visits as they work through...

great blog @ME/CFS Skeptic - thanks to you both

On Zepbound:

We've split off the discussion about abdominal vascular compression syndrome and related matters to a new thread: Gut compression syndromes; Nutcracker syndrome; Abdominal Vascular Compression Syndrome

There's some discussion about matters related to Forward-ME here (follow the arrow in the quote header)

An interesting paper from this New Jersey team. They suggest that the problems of less efficient brain function, essentially the brain throwing a whole lot of de-synchronised effort into producing motor outcomes that are similar or worse than normal, that they found during the acute Covid-19...

That youtube video by Eiko Fried linked in the tweet above is great, well worth a listen. I'll put another link here in case something happens to the tweet: In the last section, he comments that the same criticisms have been made about research into other sorts of therapies and mentions CBT...

Thanks SNT, a glossary certainly helps with this one.

I think it's important to call a spade a spade. If we call it a functional digging implement, people will be confused, and think it might be a term that they can accept and even be proud of. 'Functional disorder' and even 'conversion disorder' leave room for a lot of ambiguity for the patient...

:cry: So very sad. Thanks David for posting these testimonies. Edit I've just read Naomi's blog and it is extremely good, well worth reading

I wonder if McEvedy and Beard would have been interested in the Royal Free outbreak if there had not been a number of cases of persisting illness following the acute illness i.e. what seems to be straightforward ME/CFS? Was their dissection of the outbreak a means to suggest that the persisting...

Thanks Kiristar. There's a paywall to make comments on the article, but if anyone wants to use any or all of my post to build their own comment, please do so. Comments signal to the paper that there is an interest in the topic.

I think this was an interesting paper, making good use of retrospective data. It seemed to me to be well done, with good recognition of the limitations. Thanks to the authors for their ongoing interest in ME/CFS.

Ideas arising from a recent van Campen study: undertake analysis of cerebral brain flow (CBF) and cardiac output (CO) upon orthostatic challenge in all ME/CFS patients, not just those reporting orthostatic symptoms and not just those with a normal HR and BP response to tilt testing. compare CBF...

Limitations/ future research ideas: Yes, good ideas: undertake the analysis in all ME/CFS patients, not just those reporting orthostatic symptoms and not just those with a normal HR and BP response to tilt testing. compare CBF and CO measurements on good and bad days investigations into the...

On possible mechanisms Of course, this study only looked at people with a normal response to the tilt test in terms of heart rate and blood pressure. Blood pressure may be changing with posture in some people at least some of the time in order to try to maintain cerebral blood flow. I've seen...

These paragraphs from the discussion are worth reading: It would be worth looking at these papers that have evaluated the use of compression garments. I'm not sure how you could blind such studies, and so any reported benefit would either need to be both sustained and substantial or...

The flow was the sum from the carotid and vertebral arteries. Stroke volume was the velocity of blood passing through the aorta in one heart beat multiplied by the (corrected) aortic valve area. So, the speed of the liquid and the size of the pipe. Cardiac output (CO) was the stroke volume...