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If something is published in Japanese it either means that the international journal industry is not even interested - which has to be pretty bad - or the authors do not think it is even worth trying. I think one can assume that something published in Japanese is not going to make a quantum leap...

Yes, you can afford not to try because all that stuff about targeted supplementation is almost certainly nonsense. There are no ME doctors who know which supplements to recommend for ME. Any doctor who does is a phoney. I personally think it is very unlikely that any supplements are relevant...

Bastian is still talking of limiting damage but to my mind no damage has been done. On the contrary, the civil war at Cochrane has reminded us not to take it as an authority. People might say that some sources have to be treated as more reliable than others, or we have no idea what to think. My...

The Japanese study shows an apparent shift in activation of some phagocytic cells. That may something that happens as part of inflammation but it may occur for other reasons - so it is not a direct indication of inflammation. Whether Younger's findings relate to the Japanese is I think so far...

I hope this proves to be a real lead. Unfortunately, Cort Johnson does not give us a clear story and certainly not enough actual facts to make much sense of. Lactate is not a marker of inflammation. It is a marker of a shift in metabolic pathway. And so far I thought it had only been found...

Dear @Tilly, I very much appreciate your situation but I think it is important not to overestimate what is known about either the illness or its treatment. Ron Davis certainly does not yet know anything of use to a doctor. And I doubt making a diagnosis of POTS tells us much because the POTS...

I agree that an OT report might be very helpful.

I think this needs care. A letter with a diagnosis from a private practitioner, especially if in the alternative medicine network is likely to raise the suspicion of FII rather than lower it. I realise this is a no win situation but it would be a pity to make things worse.

I am not sure that it need involve 'effort'. Using chemical energy does not necessarily equate to effort. The chemical reactions involved are all 'downhill'. In a sense it was the plants that made the effort to create the carbohydrates and fats that we pour down the drain. I see the point but I...

I actually think this analysis is wrong, or at least misleading. I am pretty sure the thermic effect of food is part of the basal metabolic rate, not an extra. And exercise can be a large proportion of calorie usage. When Ranulph Fiennes and Mike Stroud tried to walk to the North Pole they had...

I think there is an important difference. Psychologists are to psychiatrists what physiologists are to physicians. The first is someone who has theories - abut how minds work or about how the body works. The second is someone who treats illnesses of the mind or of the body. In both cases that...

It certainly is and I appreciate the impossibility of your situation. However, I would query whether one should take too much notice of what Melvin Ramsay said. When I look this account I get the impression that he was not a very rigorous observer. He is popular because his name is associated...

It certainly is and I appreciate the impossibility of your situation. However, I would query whether one should take too much notice of what Melvin Ramsay said. When I look this account I get the impression that he was not a very rigorous observer. He is popular because his name is associated...

It almost certainly has to do with sites of tensile force in continuous postural muscle action. Most muscles in the body are called on to do specific jobs intermittently. But trapezius and soleus (which is in the same place as gastrocnemius) contract almost constantly just to keep your body...

It may be like insulin and diabetes but whatever it is does not look likely to be something like lactate. And the problem is not so much that findings are inconsistent. As far as I know measurements are just normal. Maybe finding it impossible to do any significant activity, feeling ill, and...

The problem is we have no idea.

It does not really get to the meat of the matter for me. The sentence: Such a public spat however, is unlikely to be good for science or evidence-based medicine, and indeed may have some wider implications for some fundamentals of science and science communication... seems to me wrong. It is...

I usually go by abstracts. But if an abstract 'spins' in the sense of coming to a conclusion that is not already evident from the data presented then for me it is heavily marked down, or very likely binned. Good scientific studies are not hard to assess from an abstract. The conclusion is not...

I think definitely not. Foci of tenderness in muscles occur normally anyway, unrelated to activity, particularly in the trapezius. I think this is a bit like the tender points of fibromyalgia - it does not mean anything useful. These are just the points that tend to be tender in everyone. I...

You don't really need to worry. The only things that citation number really matters for is promotion and tenure. These people are all professors already and mostly retiring.