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I don't have time to post the studies (I have posted them all in one post previously), but no RCT has found SSRIs effective for ME patients for any symptom, including depression. So SSRIs are not evidence based treatments. There is some evidence for tricyclics to be effective for sleep and...

Yes, the lack of communication is quite disappointing.

The primary function of Glucocorticoid receptors is metabolic. Hence the name Gluco... Sounds like Hell to me...

Exactly. They frequently talk about doctor shortages, but there has long been a surplus of medical school graduates. The only "shortage" is the money for training doctors.

We do get hit within a short period of time after the activity, it is just the worst seems to come 24-48 hours after exercise. The muscles used directly in the activity are hit much harder than any "PEM" that affects the rest of the body.

I don't paint! I knew I was doing something wrong. :laugh::laugh:

There have been some further questions and answers by one of the authors that some may find interesting. The conclusion is that while haematological factors are central to VO2Max, blood volume might not always be the rate limiting factor. One of the authors suggested that peripheral factors...

It's still basically a questionnaire item.

In many patients it is within the same range as controls and even when it is not, cortisol secretion patterns during the day is directly related to day to day metabolic demands and sleeping rhythms, which can often be quite different in a person who is not working full time versus someone who is.

yes, they need to correct the mistake. It's worth writing a comment that the abstract is wrong on Pubpeer at the very least.

The problem is they didn't measure fatigue. They recorded responses on a questionnaire (which was never tested for quality, in terms of relevance/understandability etc), at two time intervals and the questions themselves were retrospective and potentially subject to a variety of biases. So any...

You are aware of the problems yet you use poor quality instruments anyway? A poor foundation means poor results. Just because developing an instrument properly can be time consuming doesn't mean it should be avoided. You said you are not attempting to generalise, but that is the primary...

Funny how they conclude that increased cytokines and cortisol is a good result. Such findings may simply be due to different activity patterns before and after. I really don't know why you'd design a study like this, but... meh

The abstract is interesting, but well, highly speculative. Direct link here: http://mjms.mums.ac.ir/article_10458.html Article is in Persian.

Would be treading a fine line. Often journalists promise an expose and end up with the opposite portrayal - hypothetical: how patients are anti-science/holding back science and rejecting treatments

Seems wrong to me, there is an association with blood volume, but it is not the only association. It is intriguing though as my major PEM symptoms are circulation related. The performance drop on the 2 day CPET in ME patients is primarily lower power at the ventilatory threshold, rather than a...

So she can't answer the one question we want the answer to. :wtf:

The logic is somewhat circular though - questionnaire answering behaviour about self-compassion is associated with questionnaire answering behaviour on questions relating to stress and medical adherence. Since they are not measuring behaviours (self-compassion, experience of stress and medical...

Those exciting findings won't happen without research. Yossarian is stuck performing endless missions while Orr is planning his escape, but no one listens... Yes there will be vultures, but they don't have to be the ones who are funded. It is not about easy money. But the goal is to build...

This is not true. It is the in power of the government to set research priorities with ringfenced funding with the express goal of building research capacity. It happens in Australia (albeit not for ME), so why not the UK? ME is exceptional in terms of lack of funding compared to societal...