Search results

I know of another meta-analysis that suggests the opposite - studies do not consistently show VO2peak on the first/only CPET. The reason for inconsistent results is that patients in some studies aren't actually exercising to their true VO2Max due to lack of consistent motivation between studies...

This study is not bad, but crap design as far as CFS and PF criteria used, along with the use of poor quality metrics such as the Chalder Fatigue questionnaire limit the generalisablity of what otherwise would have been a good quality study. There is also an assumption that it was the...

Yes, those headlines are 20 years past their use-by date.

Illness duration almost certainly affects cognitions specific to how patients report symptoms to medical practitioners and on questionnaires. My argument is the opposite of the authors, namely that such changes lead to more accurate reporting, with reduced bias due to optimism and the various...

So it seems that mediums have different health questionnaire answering behaviour than non-mediums!

This manuscript is quite interesting, though inconclusive due to lack of research. I must admit I was quite put off by the fact that it was coauthored by Trevor Marshall. I'm expecting this article was mostly written by Amy, rather than Trevor... Also, "Autoimmunity Research Foundation...

So very true x2!

This is vaguely interesting - the question is are these directly involved in fatigue signalling mechanisms or are they merely a nonspecific side effect of different activity patterns of people who happen to be suffering from severe fatigue.

Oh, that's awful. I regret asking now.

Viral transmission waxes and wanes from year to year.. There was a japanese study that examined AFM cases - most were attributed to enteroviral causation and the rest were due to Guillain-Barre syndrome. It may be the latter cases which make it difficult to conclusively prove the former...

I'm going to end all wars!

No really! Certain other Dutch researchers (think Nijmegen...) claim that actigraphy is not an important outcome measures because patients often have the same activity levels as healthy controls!!!! Secondly, although they claim that patients with very low and very high amounts of sleep were...

I wonder how well these people are now?

Sigh. This is the problem with assuming that a questionnaire is actual evidence of improvement after an unblinded intervention. These interventions may be effective at changing cognitions with respect to how patients report symptoms, but this is not the same thing as objective improvements in...

Evidence for HPA axis dysfunction in ME or CFS patients in general is very weak/inconsistent and any small groupwise differences found could be due to a few patients having another illness, or simply due to different day to day activity patterns between paitients and controls. I get quite...

I see the BMJ Christmas special is in full swing. "Is it time to start using the emoji in biomedical literature?" https://www.bmj.com/content/363/bmj.k5033

These authors are HARKing and or fishing for corellations in their database. They have published multiple studies so far and don't appear to be correcting for the fact that they are testing many hypotheses. The increased association is weak and any genuine association may simply be due to...

AUC of ~0.75 is interesting, but quite poor as far as biomarkers go. On the other hand, I'm glad they did this analysis - it should be mandatory for anyone doing a study on prospective biomarkers.

The question remains, is Nick Duerden still ill?

Has anyone else not heard of IAFME before, or is it just me? Also, the Australian signatory group only represent a single state and not Australia as a whole... Never happens. ;)