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Does anyone have any updates on this - the James Lind Alliance PSP?

It's clear as mud. They need to be much clearer about what they are referring to. The key is the timeframe - the claim that one third improve by one year most likely is based on time of acute onset - a third improve somewhat until their illness plateaus. But the PACE trial did not involve...

Seems to me there is a lot of "politics" going on behind the scenes on this one...

That is quite a bold ask, "peer review" generally means people with the same interests...

It's good, but doesn't mention the alternatives: Objective outcomes Comparing psychotherapies to a drug arm and a pharma placebo arm. Yes, the set of biases are different between pharma and non-pharma, yet it elicits some placebo and reporting bias effects in the pharma placebo arm.

:walkingdead

Tom Jefferson was, until recently, more controversial than Gøtzsche. People who say, hey, there is a lack of evidence for a popular drug or vaccine tend to be given certain labels...

It's not merely waking time, but differences in activity patterns, using alarms vs not using alarms etc. The primary purpose of cortisol is metabolic and is dependent on daily activity patterns/habits.

The persistant symptoms were (1) Intestinal symptoms (2) Back pain or (3) "other" (open question). The overall "persistancy rate" of around one third is interesting. But studies like this, which are still ultimately retrospective cohort studies - even if those candidates are selected as part of...

The study in JAMA also demonstrated some effectiveness, but had the following conclusion: https://jamanetwork.com/journals/jama/fullarticle/188004

Most of the studies on neurocognitive functioning in adolescents with CFS tend to be quite severely biased towards substantially higher than average IQ and less severe functioning. These studies also tended to not test the fatigubility, that is to say the decline in performance - some used just...

The error is they chose to push a pseudoscientific ideology, rather than actually spend the billions characterising the reality of the hypothesised mind-body connection and developing an deep understanding of these illnesses.

From memory, Wessely has commented that retrospective studies are necessarily inconclusive too...

Thanks, glad there is a transcript.

https://abdn.pure.elsevier.com/en/persons/christopher-burton https://www.ncbi.nlm.nih.gov/pubmed/27569909 Morton L, Elliott A, Cleland J, Deary V, Burton C

tl;dw: yes

I agree with most of what Goldacre has to say, it just seems this is a blindspot of his and we know why... “There are all kinds of courage," said Dumbledore, smiling. "It takes a great deal of bravery to stand up to our enemies, but just as much to stand up to our friends.”...

There is also an age based effect, depending on what someone was exposed to prior to ME - I became ill when young, initially I didn't get out much but when I started to go out, I caught whatever was going around. Older people may already have been exposed to most common pathogens and therefore...

But those might not be the factors that led to the association - unless they publish the individual factors, it's merely speculation on your part. But infection, not necessarily viral does seem to be associated as a precipitating factor of a majority of ME cases (as opposed to stressful events...

I'm sure there are better ways to increase leisure time physical activity than becoming OLD!!!!!