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I hope this study is used as justification for funding of future studies (since there are a lack of high quality epidemiological studies), rather than as an intellectual exercise.

That is one of the indicators of peak effort, but is not the sole indicator. My RER peaked above 1.1 more than a minute before I reached the final VO2Peak during my testing (on the first day). The ventilatory threshold is the knee in the curve when you plot total ventilation vs oxygen...

Wow, that's highly speculative and a strange thing to suggest given the nature of the study.

What signaling mechanisms can you name that do just one single thing and interfere with nothing else? Evolution guides biology and drives pathways to be used for related functions when it confers a biological advantage. This leads to a hypothesis: The likely answer is the hypothetical...

The VO2Peak can easily be affected through motivation, experience doing the test etc. I don't believe that a true VO2Max has been achieved by many of the ME CFS participants in both the 1 day and 2 day cardiopulmonary tests reported in the literature, due to inconsistent motivation and other...

The point of discussion was the variance in performance in healthy people between the first day and the second day of a 2 day CPET.

The "training effect" is becoming more comfortable with the testing procedure and your level of performance. You don't expect to do it perfect first time right? It is the VO2peak that is often improved slightly (1-2%), the ventilatory threshold etc. is normally unchanged.

This sort of research might not be exciting, but I don't agree that it's useless.

I had lots of ear infections when young along with needing grommets.

What you are suggesting is a double edged sword - the presentation and recording of the symptoms are not the symptoms themselves and may reflect those same biases you mention, while the underlying illnesses were genuine.

Exactly!!!!!

I think perhaps you're missing the point. The fact is that bullying is still common in our society and talking about it openly, rather than just saying, "hey, that's the way things have always been, move along," is the only way it is going to change. Yes men can be the victims of bulling, but...

Excellent, the reply is nice and concise and rebuts the central point.

Exactly. CBT has been shown to be effective at changing cognitions in CFS patients, at least when it comes to answering questionnaires. The problem is that questionnaire answers are biased in unblinded trials and there has been a lack of evidence of objective improvements in disability. Sharpe...

If specific researchers insist on methods that are considered strongly flawed in other fields, then they should be discouraged from doing research. On the topic of respect, there researchers have not shown respect for patients - the deviation from the protocol is a deliberate attempt to...

Sure, but the key is that deconditioning does not explain the symptoms of most patients.

Most RNA should be found in the nucleus of the cells, not the serum. If it is found in any kind of pathogenic amounts in serum, something has gone very wrong.

The problem is that if you limit the exertion to 50-60% of max heart rate, you aren't going to build any fitness. This type of therapy is purely psychological. The same goes with the fad of high step counts - it is intensity, not step counts that builds fitness or strength. Higher activity...

I agree this would be an interesting question, along with measuring OI specific symptoms post exertion. Personally, I only experience OI after substantial exertion (for me), but it occurs sooner than the rest of the post exertional exacerbation.

Not yet published. Curious to see how many studies were included - given there are several other studies with similar results that are not yet published as far as I know.