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The dispute was over opioid pain killers - the young woman was in a lot of pain, but the Mayo clinic, with all the controversy about the "opioid epidemic" took her off those pain killers and that is when the dispute started. Mayo is unwiling to be transparent about their actions - so clearly...

The HR of 5.31 shows a trend towards a risk for Guillain-Barré syndrome. Note that this is a relatively rare consequence (around 1/100,000 person-doses reported in other studies of vaccines) and this study simply does not have the statistical power to detect events of that frequency with...

It looks like Jake is going to speak out in support of the participants, which is certainly an interesting twist.

Wow, that's awful! There is something really messed up in our culture when medical practitioners use such dirty tactics in retaliation.

The difference (in this case) is that prominent people involved with the Cochrane collaboration were the ones making the criticism.

Quite right. A lack of specificity of an association means it is likely not to be causitive. I mean you can't blame total resting, continuing to do the same amount, and everything in between as a specific prognostic factor.

Actual article is here (in Spanish): https://www.actaspsiquiatria.es/repositorio/20/114/ESP/20-114-ESP-125-32-297763.pdf The descriptive statistics are shown in table 3. They used the 1994 CDC criteria. The highest (mean) score for those with "personality disorders" was 1.69 which lies...

The alterations observed in the study are trivial and easily reversed as the person resumes their regular routine. I'd love to be able to exercise regularly (cycling, orienteering etc), but despite trying my own modest exercise program over several years, I haven't been able to increase my...

Reminds me of Andrew Lloyd frequently claiming CBT works when speaking to the media. (conveniently forgetting that his study found no effect compared to a medical placebo).

Who the fuck calls a trial "Fatigo" anyway? Clearly they don't like patients much.

The only meaningful cytokine association regularly reported in the literature is TGF-Beta, and well, they didn't test for that in this study. White even did a systematic review highlighting TGF-Beta so its absence is notable.

Claiming there could be a ceiling effect and not providing a histogram/visualisation or statistical test of the effect, leads to the claim lacking credibility. You'd lose marks doing this on an undergraduate project, it's simply not acceptable from professionals.

The trap of circular reasoning...

Thanks for sharing your experiences. The blood tests will hopefully be interesting. There is no stopping and starting, I'm not sure where you got that idea. The only difference between tests (in different venues) is the power level of warmup, the length of the warmup and the rate at which the...

Wow, that shows substantial bias on the part of the authors right there. Glad Crawley called them out on that one.

Not that I know of. It seems strange that a hypothesis presented over 20 years ago has not only never been confirmed with reasonable evidence, but is assumed as a fact by some people.

I really don't know as there are no consistent HPA axis abnormalities in CFS studies so far.

This is a pilot study, it is designed to inform future studies, not demonstrate efficacy.

Here is my quick summary of all the data I have seen so far: van Ness 2008 Difference in Ventilatiory threshold Oxygen Consumption (VTO2) Reduction of workload at ventilatory threshold not reported Vermulen 2010 Reduction of workload at ventilatory threshold (difference between patients and...

They have all found issues at the ventilatory threshold at day 2 - it is the VO2peak that varies from study to study, I suspect it is because not all participants are reaching a true VO2Max.