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The bed rest studies of the US and Chinese space programs more or less agree - healthy people recondition relatively quickly after prolonged bedrest...

He clearly has an ulterior motive - why would he suddenly respond now after years of ignoring us? Perhaps he is trying to collect "evidence of harassment" to share with others?

I've had a hypothesis around dysfunction of lipid metabolism for a while now, but dismissed it given certain mito evidence... Now having another think.

I'm not at all impressed by either of the KPAX studies, I think it is time to conclude this treatment is not effective. If you need huge sample sizes to even achieve p<0.05 it means the treatment barely works at all. There is a difference between how patients may report symptoms and their...

I'll also add this study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079947/ Sleep. 2011 May 1; 34(5): 671–678. Published online 2011 May 1. PMCID: PMC3079947 PMID: 21532961 Sleep-Wake Behavior in Chronic Fatigue Syndrome Examining the objective evidence, it is clear there is no "boom"...

A running event for CFS patients is hilarious. No one would turn up. The article is certainly a bit confusing but ultimately harmless as few people will make opinions based on it...

Yes, it's funny how BPS in practise means psychological therapy. The external social/societal issues that hold disabled people back are rarely if ever challenged, even though that is a central pillar of BPS...

Seems to be a bit of a chicken vs egg thing with not enough local demand for a biobank vs researchers becoming more interested in doing research in the field due to access to a biobank...

What a load of non-factual nonsense. The claims about perfectionism/ambition etc are contradicted by the equivocal evidence which has tried to identify such factors. Likewise, a majority of patients do not suffer with ongoing stress/anxiety/depression so the lack of sensitivity of this...

I am curious to hear how you achieved this? Yes, Vogt is deliberately trolling us presumably with an expectation that people will waste their time with him and not focus on other more important people/issues.

Right. It's ultimately about reducing costs for insurance companies and public health systems by not spending money on exhaustive testing and interventions for people with medically unexplained symptoms. Michael Sharpe has spoken at length on this topic for a long time. That's why they want to...

Those are some of the best insults I've ever heard!

I refuse. I will keep opening tabs until my browser crashes.

It's like when someone offers you chocolates, only the chocolates left over are the ones with nuts and neither of you like nuts. PS "Bodily stress syndrome" sounds completely meaningless. The word "stress" in general is extremely non-specific.

Probably that it's achieved "textbook status". (not always a good thing :whistle:)

The step test is well established (in healthy people at least) and I believe that formula is an empirical one from a linear regression comparing VO2Max with step counts.

To the above tweet Michael Sharpe simply said "Except it doesn't." It is clear he does not give a shit about patients.

Who cares? They used the most non-specific criteria possible (Oxford) and still had zero change on the step test and trivial changes on the 6 minute walking distance test (albeit which wasn't conducted in a high quality manner - has been criticised that making people walk up and down a short...

Yes! These people have never bothered to listen and understand our point of view. They continue to mischaracterise our augments as it is (politically) easier to fight a strawman than actually listen and engage. None of us are saying that the mind cannot affect the body or vice versa, we don't...

Plot of sensitivity vs specificity for a given threshold for a given (quantitative) instrument. The greatest "area under the curve" gives you the optimal accuracy for that instrument for that data set - and then you try to replicate that result on other data sets to see whether that threshold...