Search results

I think it is worth noting that the CSI is biased to diagnosing women as having central sensitisation. There are two questions that relate to urinary tract infections: and one on pelvic pain Women are more likely than men to experience bladder infections, endometriosis and period pain - all...

Essentially yes, although the details are slightly different. Substantial effort went in to selecting GPs who supported the idea of central sensitisation and who had experience in explaining it to patients. It was the GPs who selected willing patients and who decided which one (or more) of...

Yes. Although the differences in BMI, smoking and activity levels between the fibromyalgia and sex and age matched controls aren't massive. And the differences in the incidences of infections are surprisingly large. I agree, it is an interesting report.

A discussion about the prevalence of various sorts of involuntary movements has been merged into an existing Symptom Discussion thread: Involuntary movements: Seizures, tremors, tics, twitches, myoclonus

When a test was negative: GP 13: “Not that I think it will make me doubt the diagnosis, but I did have a story in mind and then I couldn’t explain it that way anymore. So yes, then I had to stop and think what to say instead.” :rofl: What an utter embarrassment - this is modern medicine.

Yes, the survey is circular nonsense. 1."Central sensitisation" (having symptoms without any identifiable pathology) has this set of symptoms with no identifiable medical cause, 2. You have these symptoms and I haven't identified any medical cause, 3. Therefore you have central...

Another account attributing benefit to enoxaparin treatment is now at [Case Report] Treatment of Long Covid with Enoxaparin, 2025, Wright, Kell, Pretorius, Putrino (some posts have been moved there)

Yes, although it's easy for people to say the perception of fatigue of the healthy males after some bicep curls or whatever is quite different to the perception of fatigue of the people with ME/CFS. And, to some extent, they will be right. Definitely this. Contexts will vary things so much...

I think the way people like O'Sullivan get around the issue of patient confidentiality is that they 'fictionalise' their examples. I think they usually say that their examples are amalgams of real patients. Which is all very well, in terms of concealing patient identities, but it also means...

How about The ME/CFS Peer Review, or just 'The Peer Review' (given that you often cover topics beyond ME/CFS) There are two of you, a pair. The name sounds authoritative, while not claiming to be above those whose work you are scrutinising. 'To peer' is to look hard; the UK Peers in the House...

I like "ME/CFS Skeptic", but perhaps that is partly because I knew what to expect when I first read one of the blogs. I think ME/CFS Science is too bland and forgettable. It will be hopeless to search on. I like ME/CFS Scrutiniser, with or without a 'k'. Others have mentioned words to do...

GNAI2 googled snippets

On TSP1 (thrombospondin-1, THBS1) US: Annual ME/CFS Working Group Meetings from 2020. Stanford/OMF

All that said (re my post), GNAI2 and TSP1 proteins do look to be different (both increased) in some of the LC cohort, compared to the other two cohorts, and so maybe are worth keeping in mind when looking at other 'omic studies.

I like the introduction. I like that there are matched groups of Long Covid, recovered and healthy controls. Group sizes are small though. The symptoms are a bit random. Numbers of the Long Covid group (total 15 people) with the following symptoms: Smell and taste dysfunction 4 Fatigue 4...

Yeah, unfortunately it's a bit questionable. For example: Participant 2 had physical deconditioning, anosmia/ageusia and difficulty concentrating when they gave the sample. But they are categorised as being in the 'asymptomatic' group. Participant 4 only ticked the symptom box for physical...

If anyone is familiar with the technique used to identify the proteins and feels inclined to describe it here, that would be great. They then did a PCA analysis and found that the PCA analysis of the sera divided the participants into two groups, one with mostly participants asymptomatic at the...

Hmm, this study comes across as overly definitive and over-confident in the abstract. There are no recovered controls, so they avoided major clues that might suggest that some of their findings are just noise. As for 'asymptomatic PCC', surely that is an oxymoron?

Thanks @forestglip. Chart 1k confirms what I had calculated: 9/14 fully recovered people were men (64%); 8/21 LC were men (38%). The finding is a bit interesting, but the sample sizes are too small and the definition of LC too loose to say much. Only 5 fully recovered women, and the...

An odd definition of severity, not related to impact on function, only number of symptoms. It doesn't sound as though the control group was well matched on sex. It's possible that what is reported here is just the result of sex differences. Figure 1B is difficult to interpret, but I think the...