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  1. Jonathan Edwards

    Anyone Treating the Eight Herpes Viruses with Antivirals?

    My memory is that Davis did not find any evidence of more viruses either. But Lipkin is a professional virologist. Davis would have made use of other people's expertise. If Lipkin found nothing I think one would need some fairly strong evidence to suggest he had not looked hard enough.
  2. Jonathan Edwards

    Anyone Treating the Eight Herpes Viruses with Antivirals?

    How could anyone know that? There is no reason to think sequestered virus would be more common in ME as far as I am aware.
  3. Jonathan Edwards

    Graded activity is an important component in CBT to reduce severe fatigue: cancer survivors (Knoop et al., 2019)

    But it sounds as if they are saying, by analogy that after treatment people are no better at coping with spiders, they just say they are. (Which I would be prepared to bet is because that is what they think they are supposed to say!)
  4. Jonathan Edwards

    Graded activity is an important component in CBT to reduce severe fatigue: cancer survivors (Knoop et al., 2019)

    But is any of this reliable evidence or just spin? Macmillan give no references. The systematic reviews we have seen on exercise for fatigue are dreadful by and large.
  5. Jonathan Edwards

    Anyone Treating the Eight Herpes Viruses with Antivirals?

    Lipkin and Hornig reported this maybe three years ago. But being negative findings I am not sure I ever saw a publication.. I think there was something that included finding some odd viruses less in ME, but not ones that seemed likely to be relevant clinically.
  6. Jonathan Edwards

    Graded activity is an important component in CBT to reduce severe fatigue: cancer survivors (Knoop et al., 2019)

    I may be misinterpreting the paper but it looks to me to be disproving that activity is actually any use in post cancer fatigue.
  7. Jonathan Edwards

    Graded activity is an important component in CBT to reduce severe fatigue: cancer survivors (Knoop et al., 2019)

    But hang on, these authors seem to be saying that it isn't actually more activity that makes people better at all. It is just that if they think they are doing more they will say they are better. Are there actually any studies that, in contrast, suggest that doing more activity actually mediates...
  8. Jonathan Edwards

    Graded activity is an important component in CBT to reduce severe fatigue: cancer survivors (Knoop et al., 2019)

    So it seems that next time they do a trial, or indeed when they do routine treatment, they will have to, in the information sheet for patients, explain that the treatment involves persuading people to think they are doing more, even though doing more does not actually make them better, it is...
  9. Jonathan Edwards

    Graded activity is an important component in CBT to reduce severe fatigue: cancer survivors (Knoop et al., 2019)

    I don't actually see any reason to think that is necessarily so. What is post-cancer fatigue anyway? I am not aware of ever having come across someone who had prolonged fatigue after successful treatment of cancer. And I have looked after sores of people in that situation. I strongly suspect...
  10. Jonathan Edwards

    Graded activity is an important component in CBT to reduce severe fatigue: cancer survivors (Knoop et al., 2019)

    From the introduction: A previous study of our research group showed that an increase in objective physical activity did not mediate the effect of CBT on severe post-cancer fatigue [6]. This was also found in CBT for chronic fatigue in other patient populations (e.g., chronic fatigue syndrome...
  11. Jonathan Edwards

    Graded activity is an important component in CBT to reduce severe fatigue: cancer survivors (Knoop et al., 2019)

    I need to read the paper but this seems a but crazy. I thought CBT for fatigue consisted in persuading people that is they were more positive about doing more activity they would discover they felt better. So the CBT group without activity would be told that if they were more positive --- er...
  12. Jonathan Edwards

    BMJ Editor's Choice: "The miracle cure"

    Nice to see her recommending a review of over diagnosis by Henrik Vogt too. Cheap and cheerful - no need to find out what is wrong - better to leave it as medically unexplained and do lots of exercise.
  13. Jonathan Edwards

    Anyone Treating the Eight Herpes Viruses with Antivirals?

    Recent studies by people like Lipkin indicate that the viral load in PWME is no different from normal.
  14. Jonathan Edwards

    Per Fink awarded the "Civil Courage" prize, Sept 2019

    It is tempting to speculate that underneath all this is some clandestine organisation such as a cabal or the Freemasons. So the truth is evil now? That sounds fairly standard for certain part of the globe these days. All dreadfully Shakespearian I guess - or maybe Marlowe in disguise. I have a...
  15. Jonathan Edwards

    Per Fink awarded the "Civil Courage" prize, Sept 2019

    Would that be the Scottish Play, not otherwise to be mentioned, or is this more a case of the PFink of Denmark?
  16. Jonathan Edwards

    Cochrane review: Non-pharmacological interventions for somatoform disorders and medically unexplained physical symptoms (MUPS) in adults. 2014

    It is very lukewarm, yet there is still the sort of sloppy wording that suggests that the people doing the study fail to understand the real problems. They say: 'For all studies comparing some form of psychological therapy with usual care or a waiting list that could be included in the...
  17. Jonathan Edwards

    Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies. Gunning et al 2019

    It does not look like a rigorous scientific study to me. Almost nothing is said about controls. In general these antibodies tend to turn up I almost any situation people look for them in. Anti-muscarinic receptor antibodies have become a bit of a joke in neuro-immunology. From my perspective...
  18. Jonathan Edwards

    2020 RNZCGP /WONCA Conference in Auckland, NZ

    I think I might be gearing up for February 2021 for NZ. If there are relevant events then I might be able to get involved.
  19. Jonathan Edwards

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    Actually I think we can be pretty sure that NICE are making their own analysis. (They said they would and I have reasons to think they are sticking to that.) Cochrane reviews are a source for NICE but NICE does not use the Cochrane GRADE assessment per se. The people on the NICE committee are...
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