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My issue is that research projects need to be specific. Blood/PBMC glycome might not yield answers even if the glycome is the problem in other tissue. My family has had several cases of GBS and immune thrombocytopenia which is technically 'glycome' related as both involve attack on sialic acid...

De-conditioning isn't the same as atrophy. So long as the person maintains some sort of weekly or day to day activity (rather than being completely bedbound), they will maintain enough muscle to do those tasks.

That negates any claims that it is due to hyperventilation.

It's a pity the manuscript doesn't discuss FOI or Alem's effort at all.

I always feel worse when I cycle further (I have a throttle driven ebike but can pedal a bit). I've been riding it for almost 15 years. If breaking a fear/response loop was going to work, it would have happened by now. It's so sad that he projects his own experiences onto everyone else.

I'm usually suspicious of studies that don't quantify the rate of people who returned questionnaires versus the number contacted. The choice to return the questionnaire is a major participation bias despite the researchers claim that their cohort is hardly biased.

Yes, it only diagnoses one very specific type of SFN. There are other types of small fibre nerves but they are almost never tested. We can't generalise on the results of skin biopsies to other forms of SFN and vice versa.

We need more papers like this that speak out about the neglect of such diagnoses in so many 'global south' countries.

"Ethics of self experimentation" if she's not doing anything that would be restricted because it harms others I don't see why anyone should complain. Even if it ended badly.

Yes, this very much sounds like a natural remission. It remains to be seen whether it is a long-term remission.

A side story, but the severity of COVID-19 was largely linked to impairment of type I interferon responses during the initial period of the infection and one study found lower itaconate was associated with increased COVID-19 severity...

The article provides an interesting perspective, for it seems the "Placebo effect" is as much for the doctor as it is for the patient. The doctor believes they have done a great thing even when there is no evidence what they have done has any meaningful effect at all.

That's what happened to me. The fact is that exercise in general is a terrible way to lose weight because it takes so much time to actually do enough to lose weight. The amount of activity in this study burns a trivial amount of kcals so the null hypothesis is expecting no weight change.

Yes, what annoys me is the entire lack of consideration of rest days. An athlete doesn't do the same amount of training every day and neither should we (activity levels, not athletic training, you know what I mean). Rest days are fundamental to health.

The part that bothers me is they didn't bother to actually ask the women in the study what they thought was the cause as the first phase and then base any subsequent experimental design based on that. But no, they came up with the hypothesis without talking to actual people, generated an...

It was interesting that they withheld the actigraphy data from all of the primary publications and only published them in this study,

58% of the general population, sounds like it should be abandoned altogether due to lack of specificity.

Revisiting "The Sleeping Beauties", it's clear O'Sullivan doesn't care about letting the truth get in the way of a good story. I found this story interesting: https://en.wikipedia.org/wiki/Sleeping_sickness_of_Kalachi%2C_Kazakhstan Something in the region of 180 people were effected by a...

I can't handle it, outrage drains too much energy, but sometimes it is unavoidable.

A key aspect in these experiments is although there is flinching behaviour, the participants don't actually feel pain when the fake hands are "hurt". It is ONLY the proprioception system that is being fooled and it can be fooled because it is a system that requires real-time predictions...