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Sulfation affects metal processing - if you have a problems with sulfite/ sulfate then , depending on enzymes/ genes and pathways affected metal accumulation can happen. It may be dose dependent -add in a few additional environmental inputs and systems can' t cope .

Interesting re shoulder and neck pain.y daughter suffers from this almost continually as well as swollen glands ....i had never thought of antibodies , more acrual and referred pain

Frontiers published the international paediatric primer - given the issues with wiki this may explain a lot

And she seemingly is doing more LP research

Definitely a hormonal link- too few studies done on this aspect ( vaguely remember a similar one also being Scandinavian)

Hope you are recovered from this and back to your normal level of function

I think there is a not insignificant cohort for whom vaccination is a definite trigger. Given the ME historical links to polio i did find the temporary paralysis effect from HPV interesting - i don' t know how common this is to know if it' s significant.

Also on twitter this morning with a few responses bringing in pace Document abstract https://www.ncbi.nlm.nih.gov/pubmed/29126260?utm_content=buffer43412&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

I know of two teenage girls who have same etiology. One if whom has had a horrific time as medics do not accept HPV vaccination as trigger ( threats of foster care ti get her into school) There is a gardisil advocacy group in UK - they have a Facebook page- it may be eorth checking out. ...

You can get tested on NHS in some places - ( Teeside do it) probably a postcode lottery like many other things - list of various tests here. http://www.b12deficiency.info/b12-testing/

I could be wrong but i think biolab do an MMA test My GP didn' t have much of a clue either re B12 levels.

Unfortunately she can't tolerate B vits. Metabolism seems very screwed up. Hopefully 23 and me may provide positive routes. Thanks @Valentijn do you still have a 23andme database that she could contribute to - as she is severely affected it may have pertinent SNPs?

Cognitive Dissonance .....

There was a father whose son had an autoimmune disease trying hard to get this into Scottish Education ( radio coverage earlier this year). Change is not made easily within the Scottish system- he was having a helluva try though. It seems a great model for primary

My aunt is 69 years old. She developed ME shortly after a trip to India, although she has had numerous illnesses suggesting a poorly functioning immune system for years, together with thyroid issues when in her 20s ( partial thyroidectomy), and symptoms of a hypoactive thyroid response now. She...

worth retweeting MEA's latest trading standards tweet re Lightning process concurrently?

I would agree that some thrive ( there are those who seem to continually run on adrenaline and love it) and that we are not all wired for fight or flight - but we can become so via prolonged stress - and those epigenetic switches are inheritable ( in rodents anyway) I do have a friend who does...

ACE is a " buzz" phrase which is filtering into many aspects of health and life. Adverse effects will no doubt affect some people more than others - it will be dependent on individual situations and the support available. There is no doubt that prolonged stress presses epigenetic buttons, and...

I've emailed link to friends and Facebooked, hopefully get numbers up Tryng to find paediatrician's email - maybe count as CPD...

PR had good Rich van Konyenburg(?) info re methylation (from a glutathione perpective)