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By the way, it is being claimed that the recent PHE AstraZeneca data may be an 'underestimate' as many of those who contracted COVID had only had their booster within 2-4 weeks of contracting COVID and therefore they may not have had enough time to develop 'full immunity'. That claim is not...

The key with actimetry is not that it is an either/or, but used in addition to other measures, including measures of symptoms and level of cognitive activity.

Here is some data: Note the sample sizes are relatively small, meaning the figures are somewhat uncertain. The previously reported 80% claim was based on combined AZ/Pfizer results...

Maybe. I can't find the latest PHE data. The claim is likely to be based on retrospective estimates of infection comparing for a non-randomised (and thus biased) non vaccinated vs. the vaccinated cohort for those who showed up at a testing clinic or hospital and tested positive (I'd wager almost...

Does he have a fever? Sounds like a form of delirium.

I agree. Having said that, studies do often show that patients self-report improvements from baseline, in the first few years. https://pubmed.ncbi.nlm.nih.gov/15699087/

Sorry to hear you haven't been doing well since the vaccine! I will say however, that such symptoms after just a vaccine is interesting in terms of suggesting pathology of Dysgeusia/Anosmia!

Some of the researcher comments weren't bad, but I agree it should be emphasised that such surveys are always of low-quality and not generalisable.

None of this is particularly insightful, but I guess the narrative review could be useful for anyone unfamiliar with the field. The lack of discussion of parallels with ME, CFS and other post-viral syndromes is indicative of the lack of broader picture thinking...

https://en.wikipedia.org/wiki/GW501516 A PPAR delta receptor agonist is an... interesting idea. It has clear metabolic effects and stimulates PPARGC1A which is a regulator of mitochondrial biogenesis. The problem is we still don't understand the underlying causes and it may actually exacerbate...

Aptamers work much the same way as the antibodies used in assays. The difference is that researchers can make their own custom aptamers more easily than engineering the antibodies.

The problem is even this hypothesis (IDO2 dysfunction in immune cells), this still doesn't explain ME/CFS symptoms at all. There is too much missing in their hypothesis at the moment. I also don't agree with the reasons given for not publishing their data. Reading between the lines, it almost...

I wish such articles would clearly communicate that antibody titre is not efficacy! The delay substitutes quality for quantity and therefore may be detrimental in the long term.

I'm not convinced about this "98.5%" reliability without published data for a population cohort. Serological tests rarely have such high sensitivity. You might have nothing to worry about.

But the body doesn't have such a system. There is no system of body-wide energy homeostasis, there is only peripheral signals telling the brain not all is well in some particular part of the body. The closest to such a system is the blood glucose regulation system (which is relatively simple...

I agree, this study could have been really interesting. Measures of 2 day CPET and peripheral blood flow would have been interesting, though that wouldn't have helped the recruitment figures very much.

That is my experience of the rapid fatigability when exercising. The power we expect to be there is not there at all and any effort to push harder is also associated with a rapid increase in pain (which diminishes quickly if I back off). The remarkable part is not all of us have that...

It improves performance when fatigued, so I'd argue it is 'more good'. Or rather, a beneficial response, rather than a perpetuating factor. This is a normal response to the stimulation of the metabo-sensitive muscle afferents and is associated with 'central fatigue'. I strongly doubt this is...

TBH, I feel more energetic and focus on symptoms less when suffering from psychological stress. Of course I avoid such states as I don't enjoy it mentally, but...

Of course, because no one cares about the "social" part of biopsychosocial.