Search results

I don't see the PolyBio study on long COVID on ClinicalTrials.gov, but here are some tweets about it. ------- Amy Proal: --------- PolyBio:

Trial registration for Simmaron Research study: Rapamycin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) They will be giving a max dose of 6 mg/week to people with ME/CFS (IOM criteria), comparing outcomes between those with "serological evidence of autophagy disruption" to...

Since ME/CFS started, I've only drank alcohol a few times. I remember one time in college I drank probably two or three shots, and I became very sick. Not vomiting or nauseous, but just a very lousy, fatigued feeling. Almost immediately after drinking, I curled up in bed instead of socializing...

Link is broken. Here is a working link: https://www.ihmc.us/stemtalk/episode-70/

Referring to CSF observations above: does anyone know if the ME/CFS participants and healthy volunteers were tested at different times, in two distinct groups? Whether for just the CSF metabolite concentrations, or the study as a whole.

I'm starting to wonder if there was a methodological issue with the CSF metabolite lab test in the NIH study. 92% (Edit: 88%) of the 445 chemicals tested had a lower median in ME/CFS. All of the metabolites they reported as significant were lower. I don't know enough about the field, but does...

I'm listening to the NIH research roadmap, and Jarred Younger was saying there was strong evidence of elevated lactate using neuroimaging, which piqued my curiosity. I don't know much about what exactly they tested in this thread's study, but is it a comparable test to the Deep Phenotyping...

Improved Fatigue Management in Primary Sjögren's Syndrome: A Retrospective Analysis of the Efficacy of Methotrexate in Chinese Patients Meiju Zhou, Xiaona Dai, Fang Yuan Abstract Objective: To assess the efficacy of methotrexate (MTX) and hydroxychloroquine (HCQ) in improving fatigue...

Encephalitis lethargica: clinical features and aetiology Jonathan P. Rogers, Tomas Mastellari, Alex J. Berry, Kieron Kumar, Ella Burchill, Anthony S. David, Glyn Lewis, Andrew Lees, Michael S. Zandi Abstract Encephalitis lethargica, an epidemic neurological illness, typically involved a...

This was mentioned in a talk by Jesper Mehlsen at the IIMEC 2024 conference. (Starts around 7:29)

I've seen a few people with ME/CFS on PhoenixRising and Reddit order online WGS tests. I wonder if it might be good to do a cheaper preliminary study where researchers put out a call for people who already have their results to send them in.

I don't know the details well either, that might be part of it, but there are lots of different options for method that all produce different results, so it's probably a bit more complicated than that. I think that "mahalanobis" in the code above looks for the distances between two points...

So I found out R actually has a library/function for matching participants called matchit(). I tried it out, matching on age, bmi, and day one workload at AT. There are a lot of different parameters and methods for matching that I haven't explored, but this seems to work well. It's just...

Just quickly looking at the charts, it looks like the difference was mainly in women and/or people over 60:

@TamaraRC you might be interested in this for your insulin resistance model.

HbA1c and leukocyte mtDNA levels as major factors associated with post-COVID-19 syndrome in type 2 diabetes patients Anton Matviichuk, Viktoriia Yerokhovych, Yeva Ilkiv, Dmytro Krasnienkov, Veronika Korcheva, Oleksandr Gurbych, Anna Shcherbakova, Pavlina Botsun, Tetyana Falalyeyeva, Oksana...

Anyone know which studies they're referring to?

Study on cortisol from this thesis has a thread: Lower hair cortisol concentration in adolescent and young adult patients with ME/CFS & Q-Fever Fatigue Syndrome compared to controls,'24,Vroegindeweij

There was some discussion about puffy face as a symptom of ME/CFS: Is this something many people here experience? If so, do you experience it all the time, or only in a crash? I think I remember having puffy face a while ago, but it was temporary and might have been related to a medication or...

Zooming in more, nothing special happened this morning. The stock went up from yesterday, but still lower than two days ago. And the paper above, if it's the right one, was published in September, so I don't know why it would make the stock surge today.