Search results

Thanks for this post - so true, it really made me laugh! :laugh::rofl:!! I love how the biological, psychological and social factors are just big intersecting blobs - hey, this is crazy, but could this be a summary of the biopsychosocial model??

@Binke4, sorry I only just saw this. Use of cimetidine for its immunomodulatory properties seems to be off-label. So its not listed on official sites that list the "indications" for cimetidine. This article talks about the immune aspects of the drug: https://www.ncbi.nlm.nih.gov/pubmed/2138376...

@Binkie, I read to the end of the link you gave, but don't know what to make of it all. The cimetidine this person was taking was a much lower dose than mine. They did seem to have similar symptoms to me, but also some autoimmune stuff (positive ANA test). They seem to have drawn the conclusion...

Interesting about the mouth ulcers. I'd never thought much about mine at all until I read this stuff. The more I read people's stories, the more I realise the MECFS isn't one condition, it probably defines a collection of very different problems. The articles on PFAPA I read suggested only...

You profile sounds very much like mine, @Hutan. My CD4 levels well exceed my CD8 ones, the ratio is abnormally high. I think the pattern you describe - disproportionately high CD8 cells - is the more common one in most people diagnosed with MECFS. But I've only been tested once, during a very...

Yea, its Tagamet. I've been seeing a Clinical Immunologist at the hospital. He thinks I have a periodic fever syndrome, that is making my innate immune system spin out of control. Also known as autoinflammatory disease. Tagamet is a treatment for PFAPA, which is a periodic fever syndrome...

I posted here about ranitidine a while ago. It looked like that was helping me at first, but that benefit didn't pan out, I'm afraid. Since then, I've been placed on cimetidine. Apparently, that was the drug the doc wanted to try me on all along, but its more expensive. I didn't expect...

You mean informal logical fallacies? Formal logic is just so vapid. Yes, I know that because Socrates is a human, that means he farts too. So glad I had Philosophy to help me work that one out.

Bias is fascinating. Looking at Psychology's replication crisis, I've noticed the sources of bias are different across different fields. In Social Psychology, the bias is caused by people wanting to get published in high profile journals and get their names in the papers. Sexy, eye-catching...

There's conflict of interest and then there's bias, they're different but overlapping constructs. People tend to think of pharma money when they think of coi, but that's only one type of coi. We should be much, much more concerned about other, more subtle ones. They are really messing with our...

The far ends of the political spectrum do seem to kind of join up in a weird way and become a sort of dictatioral blob.

I've never given location or age, but they know your location anyway through your IP address.

Me too, but I worry that they may still "know" me, due to the few people that I'm friends with, the email address I provided at sign-up, and the demographics it has of me by default (my country, IP address, etc.)

@Tal, just to put you in the picture, you'll be aware now at S4ME is a forum for discussion of the science around ME. So we don't just want to hear "it worked really well, and hey I'm cured!", we want to hear about specific medications and symptoms and treatments and everything. We want to work...

I see what you're saying, @arewenearlythereyet. But would you have got the same benefit from just having had pacing and delayed PEM explained to you - the idea of having to establish what you can do each day without too much payback later? Instead of having your behaviours caricatured, would...

Haha, in my line of work, the dress code is "wear clothes, preferably clean ones". Actually, the clean part is optional for a lot of academics. Dressing down is a mark of quality in academia. Wearing a suit makes you look like a phony, like a used car salesman. It is a no-no (except perhaps in...

No, what they think is that after a "boom" we don't enjoy the sensation of having exerted ourselves too much - we confuse that very normal set of sensations with having a disease - so we crawl back into bed. Its exercise as a phobia. So, if you had a spider phobia, you probably shouldn't try to...

I think the boom and bust idea is way more nasty and insidious, @Keela Too. Its way more than a reasonable person trying to get things done when they have a good day. The idea succeeds in somehow labelling any level of activity that a patient engages in as pathological. The patient cannot win...

I think there is probably selection bias too, in the sense that if takes a lot of hard work to even get an ME/CFS diagnosis (took me three years, and I was very severely ill). Those with less persistence might fall out of the picture because they just gave up with doctors.

Yes, and the whole behavioural-deconditioning model kind makes explicit the deconditioning thing.