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Looking at all of the participants, the change in reported levels of fatigue went from an average of about 6 to 4, on an 11 point scale (0 to 10). There might even have been a little bit of unintended bias from the clinicians. Records were only evaluated for patients seen twice or more...

It's a pretty good article. It reminded me just how hard it is for journalists coming into the ME/CFS story cold to get enough knowledge to write without mistakes and mis-representation.

I'm just trying to assess the findings, as we do for the BPS and other papers, and questioning if we can really say this is a positive result. Sure, it's not a negative result. But, if the paper is not showing anything more than what might be expected with a placebo response in an open label...

I guess I'm questioning whether we can view this paper as a 'positive publication'. The results don't exceed the response to placebos that we've seen in blinded ME/CFS trials. When I look at that report, I think, 'there is no response'. They seem to have taken out the 25% of participants...

I like Alain de Botton. I've appreciated his 'The Consolations of Philosophy' when things have been tough.

I'm not being critical of the paper, sorry if it came across like that. I find the evidence for aripiprazole helping people with ME/CFS underwhelming, not the paper. I agree it's helpful that the authors published. What I don't find helpful is Janet Dafoe, who should know better, suggesting...

I guess a placebo drug dosage could be titrated according to feedback in the same way that the aripiprazole was?

To be fair, my weight change point was rather weak. When I'm in a good patch, my weight goes down because I can be more active (and vice versa when I'm not well). But I know that some people with ME/CFS struggle to take in enough calories for various reasons; so improvement in ME/CFS for them...

This is underwhelming, and I think it's premature to be suggesting that doctors should be prescribing it outside trials. First, there are no controls, so we don't know if people who weren't treated with aripiprazole would have responded similarly. It's quite likely that patients have become...

Wow. Oh, I think you are wrong, it's quite logical. You are just focusing on the wrong outcomes, outcomes like 'better health'. Think of outcomes more like knighthoods, feelings of moral superiority and insurance company largesse, and it becomes quite logical.

Yes, you are doing terrific work @Caroline Struthers. Thank you. I guess when the rewrite of the exercise review was announced, we all, including Hilda and even Cochrane, expected it would happen faster than it seems to be happening. I get that Covid-19 has slowed things down, but really, the...

As an off-the-wall and circuitous answer to the question "where will the drugs come from?": Ciguatera poisoning can cause long term sequelae that look a lot like ME/CFS - fatigue, brain fog and pain, with relapses triggered by exercise. The mechanisms are better, although still not well...

Yes, this feels like quite a step forward. A lot of the possibilities were written up rather more positively than I think is warranted though, although I understand that the purpose of attracting interest requires some hopeful statements. For example this one for NADH and CoQ10: my...

It was a fairly helpful interview, in terms of increasing public understanding of the illness. Dr Vallings does refer to the illness as CFS/ME or Chronic fatigue syndrome which is slightly annoying. She said that there's no reason to think that Long Covid is not a post-viral fatigue syndrome...

https://www.healthrising.org/blog/2021/02/01/garner-recovery-long-covid-recovery-story/ Cort Johnson has written about Garner's recovery. Cort does not appear to have read Garner's previous blogs (edit - and facebook posts), as he does not appear to know that Garner was attempting to run long...

I know that's what Swan is doing. But, he isn't the only person running the show these days, it seems. It is progress, even if it is of the 'water on stone' sort.

:) That does look like progress.

Sorry to hear about the relapse AWNTY. I don't have a SPO2 meter, but I was thinking of the tendency of my hands to go numb when elevated as I read this thread. It happened a lot to me and my two children in the first year we became sick, and it happens these days when I've overdone it. It's...

Notwithstanding this, (that PEM is fundamental to a definition of ME/CFS), I have been wondering if ME/CFS symptoms are a particular subset of possible symptoms arising from related processes during and after an infection. One of the prompts for the wondering is the case of chikungunya on...

I think the name used for the disease in this 'fully revised edition' - 'Chronic Fatigue Syndrome/ME' - is a good indicator of the likely content. Sort of right, but a bit out of date, and with more than a touch of BPS. Assuming it's like Dr Vallings' previous books, people can get better, and...