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If I had to vote on a term listed so far, I'd go for 'cognitive dysfunction'. I imagine it as something subtly altering the functioning of individual neurons.

Yet another understudied component that could be involved in ME.

I recommend keeping a food/activity/symptoms journal, as detailed as you feel up to. As you've found, human memory, even without ME, is too fallible for accurately remembering such data. A list of symptoms will help start that, but I don't have a convenient one. Search for the criteria for...

The B12 = niacin error jumped out at me too. :) What was missing from the abstract is that they only measured serum and urine levels of metabolites. Since central fatigue is neurological, and many kynurenines don't cross the BBB easily, I consider their findings to be fairly useless. If...

Even before I knew about ME, I was aware of how TRP increased my symptoms (unless I also took BCAAs), and how exertion and viral infections (increases IDO) similarly increased my symptoms, so this paper fits my observations and beliefs about ME. I'd rate this as the most important paper...

Just think about all the parts about B12 metabolism that researchers haven't even discovered yet. :)

Another older study that found something possibly useful...but was never followed up on?

Maybe these were people who didn't have ME to begin with, and found a different diagnosis. I also wonder what the results would be from people who would have fit the criteria for the study, but didn't get the 'specialized treatments'. I'm sure some would also have improved. Also, did the...

It sounds reasonable to me. I'm convinced that my glial cells are closely involved in my ME, so this fits. It might not require increased ATP; it could be other mechanisms that affect how the glial cells function, which in turn affects the ATP->damping function. Since many of us suffer from...

My ME trigger wasn't clearly an infection. A tetanus booster may have been the trigger, but the first notice of something being wrong was what felt exactly like the onset of a flu, except that it was gone the next day. A couple of days later, it happened again, more severely, but still...

Another study with limited knowledge of how varied ME really is. Some of us don't suffer from physical fatigue or a significant reduction in our body's efficiency. Some of us have the mental symptoms (mental lethargy/fatigue) without the physical symptoms: the Canadian and International...

There's a lot that isn't covered by the available methods of brain imaging. I'm not sure what the smallest range of chemical signalling is, but I expect it's only a few cell diameters. Available methods just don't scan that scale, and not at a relatively huge distance through a thick skull...

Yes, on PR, several other members stated that they didn't get physical limiting symptoms either. Some of them continued what sounded to me like pretty heavy-duty bodybuilding exercises. There seems to be a subset of ME victims who don't suffer muscle-limiting symptoms. IIRC, at least one...

Nope, haven't found anything like that in journals. It's just my theory based on observations of my PEM in response to exertion. Earlier today ( https://www.s4me.info/threads/is-me-a-metabolic-problem-or-a-signalling-problem.10981/page-7#post-290644 ) I posted a link to a paper on creatine...

Unrelated plant. No cuminaldehyde.

No, I used several no-name packages of ground cumin, and bulk seed from at least two different stores, and they all worked the same. Some exotic brands might not work as well, since cuminaldehyde content does vary with where it's grown, but the cheap stuff available here in Canada seems to work...

Repeated testing, while holding as many other variables as possible constant. With the cumin, I found a list of compounds found in it, and tried other herbs and spices that contained subsets of that list. Cuminaldehyde seemed to be the most likely chemical. I couldn't get any other source of...

Maybe because brain cells are hard--and expensive--to scan in high detail? It's hard to measure how tightly astrocyte feet are clamped around a blood vessel, or how much quinolinic acid is being produced in a small clump of cells, and it probably doesn't take all that much variance to cause...

I wonder if stress is a factor in that. Reading a technical document for self-education doesn't involve emotional stress, so it doesn't trigger PEM for me. Filling out taxes or making decisions involving large amounts of money is stressful, and does trigger PEM. Likewise, I think that talking...

That's true as far as I know. I found that in one or more papers. I think it's normal for activation of the body's immune systems (t-cells, b-cells, maybe others) to activate the brain's immune system (glial cells). The brain is critical, so the rest of the body gives it warning signals just...