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Added October 2021 A member noted in September 2019: "Sometimes when I'm in a crash (either due to overexertion, or to a different, unidentified factor), I experience an unpleasant taste in my mouth. This makes water taste rather unpleasant. It's weird. Does anyone else get this?"

Yes

Do you mean it's not Beyoncé? :emoji_open_mouth:

What about that paper that Graham McPhee and others published recently.

@Jonathan Edwards it seems they are trying to forcibly limit their "evidence" to psychosocial trials, what can we do about this?

From the registration of the trial: "The primary endpoint will be the change in the average total daily symptom score (TDSS), over 28-day periods immediately prior to the first treatment (pre-treatment) and immediately prior to exit from the trial (post-treatment). The TDSS is the sum of 13...

Just because CRF2 activation is necessary & sufficient to produce learned helplessness, that doesn't mean that LH is the only thing that it can cause. Just did a bit of googling and there seemed to be plenty of other things mentioned in relation to CRH (corticotropin releasing hormone).

Sorry, I didn't quite catch that?

THIS, this is the most important question in my opinion. It's the most bizarre medical thing that I've ever heard of, it seems to defy all 'standard' understanding. It seems unbelievable to people. Physically, there is at least some kind of precedent in terms of overtraining and injury and...

OK so If I eat less than usual on one day, and my energy is worse, is that due to eating less or is it just a coincidence? Because doesn't it take quite a while for the body to turn your food into energy anyway? I'm trying to lose weight, but my brain is saying "go eat a packet of crisps...

I have personally found that treating (presumed) candida overgrowth has improved some of my ME symptoms. Presumed because I found that when I took a fluconazole for a vaginal yeast infection my cognition suddenly greatly improved - so I repeated that as an experiment a couple of times, same...

That could potentially explain the anecdotal reports of certain meds and supplements being helpful. Magnesium reduces the effects of glutamate by blocking NMDA receptors. LDN may increase glutamate transport. (https://www.ncbi.nlm.nih.gov/pubmed/15694688) Alpha lipoic acid increases...

It's always silly season in BPS-land.

You'd think they'd have found it by now :(

@Trish @Jonathan Edwards On the topic of calories and BMR... I have found that my calorie need (for an ordinary day where I am not overexerting myself) increased when I developed ME, and increased when my ME increased with severity. So I need to eat a lot of calories in order to function at my...

Interestingly... For some PWME, what you are talking about is the case, i.e. tiring yourself out in one muscle area leads to PEM in the whole body. But for some PWME, including myself, it will usually only lead to PEM in that particular muscle area. It is quite common for me to say "I have PEM...

If optimism can make you live longer, then I'll stop trying to be optimistic.

It would be very useful in some situations. I know somebody who has a severely autistic son who cannot communicate much at all. He recently had a brain tumour removed. Him not being able to communicate pain is a big worry for them. They would not know if he was understanding the question "are...

Lots to unpack here, but just gonna point out that that isnt even their usual definition of a boom bust cycle. That just sounds like a bust and more bust cycle.

Or they will just refuse and say the blood test is unnecessary because I don't believe you are in pain and I don't want to encourage your illness beliefs