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From Mikovits to Lipkin to Montoya, and I think a couple in between, there have been studies noting some abnormalities in cytokine production, if memory serves me. Wasn't it Lipkin who opined something about overactive cytokine production pre-three years, underactive post? More recently...

Oh, I don't know. Today autoantibodies are in favor in some camps, or some kind of immune dysfunction. Three to five years down the line, who knows? Something is causing all that cytokine/chemokine activity.

The relapsing-remitting quality might, coupled with its frequently idiosyncratic character/manifestation. This is small consolation, even if it fits. :(

It is the exact opposite for Borrelia, that is, in the absence of abx therapy, Bb titres often decrease in late stage, with abx, titres often rise. The thing they appear to have in common is treatment impacts immune response.

This would not square with patterns.

Is there built into this position the assumption that the first infection has resolved? What if it has not? Also, how would you explain antibiotics being used to see if infection persists, i.e., antibody titres rise during abx use?

Very cool. Thank you for squaring that for me. I do not want to detour from this topic, which is enteroviruses, but @Jonathan Edwards, this does not reflect what I know about bacterial antibodies, in particular spirochetal ones. For instance, the VDRL diagnostic used for Syphilis owes much of...

If I might be permitted a slight tweak of this observation, but an important one, perhaps. A high antibody titre MAY be just a sign of good immunity. I think, however, as a rule of thumb, antibody levels will peak as infection peaks; after that, they typically decline, at least to an extent...

I don't engage with neighbors or people anymore because I make so many mistakes. It is what it is.

Pretty sure this is one of our symptoms the CDC missed.

If you find one pathogen that you discover conventional medical dogma is suspect and likely errant, you realize there can be others. This is where I would place my money, at least for a subset. If you frame ME/CFS as a collection of symptoms only, then it is possible that different pathogens...

Were tissue reservoirs involved?

Any odds that critiques will pretty much fall along party lines, ie, US residents will be harder on the revisions, UK and many other European countries and Canada more pleased? This is hugely better than the BPS horror show, and it is an improvement over before, but still too much...

A couple of the links under Information for HealthCare Providers don't work for me, but it's likely me screwing it up. But this is what I want to see - what are they now saying to Healthcare providers that is different. I wish they would just come out and say most pwME do not improve. They...

Assuming enterovirises play a role (as well as other pathogens?), some of the confusion over inconsistencies in patient experience could be due to the course the disease runs. I do not know if enteroviruses are tissue-tropic, or if the virus spreads uniformly through-out the body. If it does...

I think you need to factor in degree. And I only threw in vestibular damage as an example of brain damage. I did not mean for it to be interpreted as definitive. I think there are many examples of brain damage in pwME, as well as damage to the peripheral system. POTS, for instance, could be...

Yes, periodic paralysis (thank you, I have corrected my earlier post). But I believe in most cases of periodic paralysis, there usually is little to no paralysis, just permanent muscle weakness (albeit frequently profound, debilitating weakness). There are many that have paralysis, some pretty...

I cannot speak to what Acheson was referring to, but I can tell you that neurologists have a whole category of illness called Periodic Paralsys which in most of its patients does not refer to paralysis most of the time, but instead can be characterized by permanent muscle weakness that...

@Jonathan Edwards, relative to your two bolded items, I have to disagree. Paresis doesn't only refer to paralysis, it also refers to a more or less permanent muscle weakness, which I have seen many pwME describe. Individuals with periodic paralysis - also characterized USUALLY with PMW or...

I'd like all ME/CFS research going forward to have better screening mechanisms integrated into their processes. I fear too many conditions and pathogens are slipping by when they are discreet and should be excluded as such. For instance, how are not channelopathies routinely checked for as best...