Search results

Used to be most like option 2 for many years - interestingly I was (mis)diagnosed with MS for a good part of that period - but the last few years it's been more like option 4 so chose that.

A very good question indeed. It would seem such a comparatively cheap and simple matter to replicate those studies and know one way or another. Does anyone have any further information why this line of enquiry was dropped? Were the original studies badly designed/reported and not as conclusive...

Cross-posting an extract from a comment I made in another thread, members only, because of the link to the metabolic trap (https://www.s4me.info/threads/does-being-in-more-in-daylight-help-your-symptoms.6381/#post-116102). Recently I accidentally stumbled on an interesting connection between...

Has this been posted? Not about ME but 'chronic fatigue syndrome' gets a mention. Viruses Under the Microscope, by Gunnar Bartsch, 09/14/2018 https://www.uni-wuerzburg.de/en/news-and-events/news/detail/news/viruses-under-the-microscope/

Given that most thought processes occur below the conscious level a questionnaire to elicit them seems... questionable. To say the least. Maybe they should ask patients to make puns instead. This appears to be a more accurate method as shown by the overreact/ovary-react pun on the poster...

While it may not be ideal I think the cuff test is worth pursuing, for two reasons. 1) It's something that can be used on patients too severe to ever get near a CPET. 2) It measures something: resulting miRNA patterns differed between ME patients and controls and, if I recall correctly, also...

"Ovary-reacting???!!! :woot::wtf::arghh::banghead: Read the whole post by ISHO (In Susan's Humble Opinion) here: https://ishoblog.com/2018/10/18/pass-the-snuff-and-loosen-the-corsets-theyre-back-to-researching-hysteria/?fbclid=IwAR3auNOacrDAvo08nkuRdpYynFghkQe_3kFphx5Amb-C9XoA8ygVh4ulxz0

Do report back if you can. And if you get a chance to ask, I would be interested to hear if Ros knows of any younger doctors coming through with a special interest in ME who may one day be able to fill her place.

As a general rule of thumb, ref is the original allele and usually the good one, and alt is the more recent mutation and usually the bad one. But, as I said: rule of thumb only, plus applies only to bad (pathogenic or risk) mutations. Many mutations don't do anything much (benign) so there it...

You are perfectly right of course @Trish. None of us laypeople is going to work out the solution for a problem in such a complex biological system, no illusions there. I suspect one of the reasons we entertain ourselves with much happy speculating regardless is that we suffer from a couple of...

This potential ME-trigger-to-tryptophan route is mighty confusing. On the one hand stressors and infections can upregulate IDO and TDO, potentially causing tryptophan to decrease. On the other hand certain infections (unfortunately the usual ME suspects were not tested in this study) are...

I've only read the abstract which I interpret - in/correctly? - as not referring to tryptophan synthesis but only to tryptophan metabolism, i.e. the conversion of – presumably dietary - tryptophan into other metabolites such as kynurenic acid. Does the article itself say anything more? It's too...

@mariovitali What about TDO, do you know? That's in the liver I understand but the question is could it be downregulated by any of the typical ME triggers like EBV? Or could it be generally downregulated if there were the sort of liver problems you talk about? Edit: typo - corrected TPO to TDO

You ask a lot of good questions in your blog @Jenny TipsforME, so good I'd like to highlight just a few here. This had entered my mind, too. The way the hypothesis was presented I could understand how it could explain switching into – or out of – ME mode, a sudden on/off switch. Sure, this...

You're welcome @paolo. I do enjoy your blog and often find it helpful when trying to get my head around a complex ME issue. Though in this particular case your mechanical analogy didn't work for me, too abstract for my way of thinking maybe? But I'm sure it's just perfect for somebody else; we...

As I understand it the actual trap hypothesis is more concerned with IDO1 inhibition than TDO (plus of course the IDO2 fault) but if what you say about TDO is correct, @Stewart, that could certainly be one way to explain the initiation of the trap, which is exactly what my question was. For this...

I have a possibly dumb question about the trap After watching Phair's presentation plus reading about it on a blog (https://paolomaccallini.com/2018/10/08/is-it-a-trap/) I think I understand the concept of the metabolic trap. What I don't understand is how it gets started. I get that there has...

Will the relevant authorities/people see the recent re-analysis of the ME Cochrane review? Can somebody make sure they do? http://journals.sagepub.com/doi/full/10.1177/2055102918805187 Discussed here...

Always nice to see the establishment of another ME research center, especially one featuring new (new to me anyway) names. The more the merrier! @mariovitali will find this one interesting: Jon Jacobs (my bolding) ;) Edit: corrected tag

Yes, funding organisations are typically conservative but like to see themselves as progressive and cutting edge. That's why I think Moreau would likely be one of the few ticking both boxes. No idea, sorry. But somebody at the Stanford symposium said they thought possibly all the approaches...