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Here are the 9 differentiating proteins that made it into their model: CXCL5, AP3S2, MAX, PDLIM7, EDAR, LTA4H, CRACR2A, CXCL3, FRZB All were elevated, except for FRZB which was lowered. I think we have seen something about some of these immune cell receptors before: In the limitations, the...

Ah, damn, there is no 'recovered from Covid with no ongoing symptoms' cohort. That limits the usefulness of this study. The proteins might just identify people who have had a recent infection. The blood draw was taken from the acute Covid patients upon hospital admission; the blood draw from...

A good start to the paper: Selection of the cohorts looks fine. An Ontario, Canada study. 22 people in each cohort. PEA: Proximity Extension Assay - done using thawed plasma. Basically I think, if markers of a specific protein occurred near each other, that resulted in multiplication of...

Regarding the claim that ME/CFS researchers are harassed, a great collection of quotes:

:) To quote SNT Gatchaman out of context: which sort of sums up ME/CFS issues in general really.

Umm, I think they can be very mildly hyperextended at will. Certainly my elbows mildly hyperextend at will, and my fingers can be bent back along way too. And even in my advancing age, I can sit with the soles of my feet touching each other and my knees on the floor. I've always had that...

A nice podcast from Nature Scot linked on the birds thread. Anna Wood was a very good spokesperson for ME/CFS. Not that ME/CFS was the focus of the podcast, quite the contrary, it's mostly about birds and nature photography. Feathered Friends - birds and bird-watching It just sort of...

When I got ME/CFS, I started doing one-on-one or very small group pilates with a nearby rehabilitation studio, thinking I just needed to be fitter. I fully expected to get back to normal. They did a baseline assessment of strength and of balance. I tried hard over months, starting out with...

I don't have light sensitivity. I don't have a sensitivity to foods that I have noticed. I don't have sound sensitivity, except when in PEM, when any stimulation can feel like too much, a bit like when you have a headache, you really don't want the neighbour mowing the lawn with their petrol...

sure

It might be worth the NZ members who are interested drafting a letter to Chris Ellis, NZ GP and/or the RNZCGP explaining about the problems with the idea of 'Long Covid = anxiety (at least partly)'. I hate to see training content that makes life harder rather than better for people who go to a...

Re the NZ doctor article: aargh. I would very much like to tell that author exactly what they can do with their 'reassuring, supportive and 'expectant' management plan'. Which basically amounts to a 'don't worry so much, dear' pat on the head'. There is so much certainty that such an...

Link to a recent Stuff article mentioned on another thread about a young woman in Christchurch who has developed what seems to be severe ME/CFS following a Covid-19 infection. I think it's well-written and very sad.

I read this account and get a sense of what a difference a good clinical team and a decent set of tests can make as to whether someone has a lifetime of unexplained medical issues (or worse, a functional diagnosis) or they get a diagnosis that leads to understanding and helpful treatment. I...

I've made a thread to talk about gait. It would be good to hear more about your interesting finding on that thread: Gait in ME/CFS

It's interesting to think about whether gait is affected in ME/CFS (including post-Covid ME/CFS). Of course, like most/all of the symptoms, any impact on gait will probably vary over time. It might also be useful to talk about how we can assess changes in gait ourselves and how it might be...

I don't think that's an accurate reading of my response here, or of any other member who has replied. I'm very happy to hear what an observant, smart and sympathetic clinician thinks, and even more so when that clinician also has a knowledge of the ME/CFS literature. I don't think anyone has...

Re Professor Jeremy Nicholson, quoted in rvallee's post Professor Jeremy Nicholson, the director of the Australian National Phenome Centre at Murdoch University Phenome? Metabolic phenotyping I think. Radio NZ interview - text article Prof Jeremy Nicholson: the link between Long Covid and...

I'm having a day where it is hard to think and write coherently, so apologies if my posting reflects that. Previously, but after the onset of ME/CFS, I worked on 2 consecutive days of full-day video calls where there was a lot of information to process and points to argue. I fortified myself...

You may well be right about the inhibitory signal. But, I'm not sure why the ability of people with mild ME/CFS to perform normally on a single CPET when well-rested indicates that there is no problem with the ability to sustainably produce ATP. Why do you think that? I think we have seen a...