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I noticed the article too. My thought is that they discovered a separate sleep function, and that it possibly only applies to simple brainless organisms. I don't think it suggests that we should ignore the neural-refreshing aspects of mammalian sleep. Neural sleep may have provided the needs...

The paper supports my hypotheses for ME. For quite a long part of my ME, T2 (3-5 diiodothyronine) was an important treatment for me. A single dose would block an otherwise worsening of my symptoms for a very consistent 21 days. Hampering thyroid function, and thus T2 levels, would make my...

One thing that bothered me about the ME research projects is that their email addresses disappeared. If a patient discovers something, whether a treatment or a reliable correlation between symptoms and some factor, how do they pass that along to the research community? I considered the...

How about laying in bed while a boxer pummels you? :blackeye:

If that's what it did, it could be remarketed as "Pet cat in a pill. No litter box to clean!". :emoji_cat2: Regarding the pill in question, I really don't think that it offers health benefits to bedbound people. Larger unexercised muscles might even be detrimental.

I wonder whether there's some sort of bias against following up (or funding) research that has been done x years ago, even if it's suddenly become more relevant.

Have there been a clear clinical answer to the question: "Do PWME have lower ATP production and/or reserves?" I've seen some studies saying yes, and others saying no, but I haven't seen one yet that definitively answers it. However, I think the question should be "Do all PWME have lower ATP...

Yes, I think it's the neurons involved in motivation not functioning normally. There seems to be some understanding of the parts of the brain involved in motivation, so it's not a complete mystery. I'd study that research material and try to figure out why my ME is affecting motivation ... but...

If it had been clearly labelled: "One hypothesis", I wouldn't have a problem with it. At least it's something other than "It's a psychiatric problem". Saying that the graphic explains ME is simply wrong.

I agree; it can confuse perceptions, and it doesn't apply to all PWME. My preferred explanation for how it feels is how we feel when we have a flu: we feel lousy, achey and lethargic/brainfogged overall and just want to hide under a blanket until it goes away. ... and after 20 years of this...

A good topic. As with several other posters, I do not feel any reduction in available energy or the rate at which I can use it. I believe I have a neurological disorder which impairs my ability to make the effort required to do things. My legs might feel like going for a 40 km ride (and would...

What's the goal of providing funding for medical research? Is it just to boost the public image of the donors or fund allocation organizations? Are unspecified-target donors assuming that their donations will be wisely allocated for maximum reduction of suffering in the world? Are...

How are waste products removed? If they're pumped out through astrocytes, do the astrocytes not absorb it from CSF? Regardless of the final 'waste drain', movement of fluid would be important for preventing localized buildups of waste.

Well, what do you expect from a psychologist? It's the 'if you have a hammer, everything looks like a nail' syndrome.

There was another research paper last year that explained how the slow brainwaves of deep sleep helped pump fluids from the brain. Astrocytes also open the BBB a bit during sleep to transfer waste out. I'm not sure whether they used markers to prove it.

You could tape (or otherwise attach) strips of light-blocking material to the outside edges of the door, extending past the opening. I think that would be way more convenient than a whole sheet of fabric. Probably easier than the foam strips too. If you care about how it looks, you could be...

Also, at least some parts of the immune system are non-linear (think of the result a a tiny amount of allergen to some people), so the measure of one or more inflammatory markers may not say much about the severity of ME symptoms. Another complication: maybe it's not an inflammatory cytokine...

I wonder whether anyone has considered making all medical test results available as anonymous 'big data'. Imagine if this research group could access several hundred or thousand scans to provide some baselines or variabilities. Obviously there would be problems with variables in how the tests...

Treating ME symptoms is pretty difficult, because I think in most cases no one knows what the actual cause of the symptom is. I've managed to treat some of my symptoms very effectively, but those were accidental discoveries. LDN was the only treatment I took intentionally that worked, and even...

I wonder whether that simply a bias due to education levels, economic status, or some other such factor that affects reporting of ME. It might even be that doctors in that locale tend to come from different education or cultural backgrounds, which affects their diagnosing or reporting of ME...