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Yes, but my post was just making a humorous connection to Mithriel's avatar. Poor bear. Surely finding your teddy all poked up would cause ME. ;)

I'm definitely an outlier. Others have reported ME with no loss of physical performance, but I also was very effectively treated by cumin and T2, which haven't worked for anyone else. I think that outliers have the potential to reveal otherwise hidden aspects of ME, but as you say, we could...

Adverse childhood events? As in "You developed ME because you found your teddy bear stuck full of needles when you were 3 yrs old?" ;)

That's an important part of science: establishing the reliability of new measurement techniques. Without it, a study of ME brains with this technique is just colourful pictures.

It makes perfect sense to me. You used muscles beyond their normal limits, which triggered your immune system to clean up the damaged cells, and the resultant cytokines caused your symptoms, directly or indirectly.

I suffered malaise after exertion, so that's within the definition. It doesn't say post exertional endurance loss. That didn't seem to be part of my PEM either. I felt much worse when the PEM kicked in, but I didn't notice any reduction in endurance. I expect that my legs would have managed...

Actually, I'm a poor choice for explaining the differences, because my PEM was non-standard in some ways and I never had crashes. I've simply read lots of other people report a wide variety of responses that get labelled "PEM", which I didn't experience myself. For me, PEM was simply a...

Maybe if they subdivided the groups based on astrological signs, or first letters of their names (or their pet's names), or some other such random divisions, they'd eventually find an even stronger statistical correlation. :rolleyes:

"Our research goal is to make some random numbers appear to say something we want them to say." :rolleyes:

If I had to vote on a term listed so far, I'd go for 'cognitive dysfunction'. I imagine it as something subtly altering the functioning of individual neurons.

Yet another understudied component that could be involved in ME.

I recommend keeping a food/activity/symptoms journal, as detailed as you feel up to. As you've found, human memory, even without ME, is too fallible for accurately remembering such data. A list of symptoms will help start that, but I don't have a convenient one. Search for the criteria for...

The B12 = niacin error jumped out at me too. :) What was missing from the abstract is that they only measured serum and urine levels of metabolites. Since central fatigue is neurological, and many kynurenines don't cross the BBB easily, I consider their findings to be fairly useless. If...

Even before I knew about ME, I was aware of how TRP increased my symptoms (unless I also took BCAAs), and how exertion and viral infections (increases IDO) similarly increased my symptoms, so this paper fits my observations and beliefs about ME. I'd rate this as the most important paper...

Just think about all the parts about B12 metabolism that researchers haven't even discovered yet. :)

Another older study that found something possibly useful...but was never followed up on?

Maybe these were people who didn't have ME to begin with, and found a different diagnosis. I also wonder what the results would be from people who would have fit the criteria for the study, but didn't get the 'specialized treatments'. I'm sure some would also have improved. Also, did the...

It sounds reasonable to me. I'm convinced that my glial cells are closely involved in my ME, so this fits. It might not require increased ATP; it could be other mechanisms that affect how the glial cells function, which in turn affects the ATP->damping function. Since many of us suffer from...

My ME trigger wasn't clearly an infection. A tetanus booster may have been the trigger, but the first notice of something being wrong was what felt exactly like the onset of a flu, except that it was gone the next day. A couple of days later, it happened again, more severely, but still...

Another study with limited knowledge of how varied ME really is. Some of us don't suffer from physical fatigue or a significant reduction in our body's efficiency. Some of us have the mental symptoms (mental lethargy/fatigue) without the physical symptoms: the Canadian and International...