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It doesn't show whether it's a cause or an effect. ME-affected bodies are abnormal, so there's no reason why it can't result in less ability to remove various toxins.

I think you're on the wrong pathway. I never experienced that sort of 'energy limitation'. My physically-induced PEM was triggered by what I believe was muscle microtears (caused by using muscles in ways other than usual daily activities), not by general exertion*time. My cognitively-induced...

The abstract certainly doesn't entice me into reading the full article. It sounds like they didn't find anything new, so they put their efforts into making it look impressive, or at least to intimidate readers into not asking questions.

https://osf.io/ef3n4/ The newsbrief posting reminded me that this paper wasn't mentioned. I think it may be a pretty important hypothesis for ME's root cause. It fits what I believe is the root cause of ME: that neuroglia are involved. I'm not sure whether there are any ME symptoms that...

All those projects, and I only like the one studying brain inflammation.

I haven't noticed any changes in my ME due to weather. I have a Type I allergy to something in the air in winter around evergreen trees when certain conditions are met involving temperature and humidity (and probably other factors). My guess is that something is releasing spores. Your...

How does one factor in the fact that people who get 2 doses have different mindsets than those who get one dose, who have different mindsets than those who haven't gotten vaccinated? Strong belief in the protection of 2 doses is likely to make those people underreport any symptoms.

I had, and still occasionally have, what seems to be neuropathic pains due to my ME. I consider that a symptom of ME that some but not all PWME have. I certainly don't believe that neuropathic pain is the cause of ME. Besides, I don't think they understand central sensitization either, so...

Doctors don't know how to treat FNDs, so these patients are less satisfied with healthcare services than patients with treatable disorders. Makes sense to me. Doctors who are unable to satisfy patients are less satisfied than doctors who are able to satisfy patients. Is anyone else noticing a...

At least the thread title made me smile. :)

Your poll should have allowed multiple selections for 'didn't improve' or just had one selection for 'didn't improve regardless of when taken'. None of the supplements listed affected my sleep. What has had a positive effect is CLAs (conjugated linoleic acids). Without them, I generally wake...

I hope there's some good followup research on this.

Well, I scored zero. :facepalm: It's all guessing what the 'experts' guess is correct, since they don't actually know for sure.

It may not be as simple as standard neuroinflammation, but I'm still convinced that it's part of my ME. My ME symptoms always increased with infections or exertions that would produce IFN-g, which would in turn activate glial cells. So far there's no definitive study (large, proper controls...

21 years, constantly mild with varying degrees of feeling a bit better or worse. I've had quite a few symptoms and sensitivities occur and change or disappear. I managed to cure my PEM, persistent neuropathic muscle aches, and another problem that required treating with T2, and an intolerance...

Did they compare this to any other pain reduction techniques? Maybe females are simply more likely to check 'improved' rather than 'no change' on these sorts of questionnaires.

Aside from the psycho-nonsense issue, different brain activities have different effects on overall feeling. Playing a strategy game past 2:30 PM gives me insomnia that night, but playing a first-person shooter game (mindless shooting of zombies) doesn't. Maybe some neurons deplete something or...

The amazing thing: there's probably someone out there who is actually proud of creating this nonsense. :rolleyes: Oh, and if it doesn't result in a major accolade for transforming patient care, it will of course be the fault of the nurses for not implementing it properly, or the patients for...

It could be, but it could also be just a malfunction that evolution hasn't weeded out yet. If your computer stops working because a single transistor ot trace failed, it isn't because it's trying to protect itself from further damage.

Died from being left behind because "You look fine, you're just being lazy." :(