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Excellent - well worth a read. Thanks both to @Dave 30th and Carol Monaghan.

But PACE did say in their protocol that they would use a submaximal 'self-paced step test' (search the protocol for ref #43, which is this Petrella thing): https://www.ncbi.nlm.nih.gov/pubmed/11380757

Not necessarily - I think a lot of UK PWME give to quite a range of ME charities, including overseas ones. That will often include the MEA, of course, but not exclusively so.

How about changing your title to 'David Tuller's new crowdfunding campaign (April 1, 2018)'? Important to have your name on it so people read the thread, I reckon.

@JenB - this is awful. How about a UK-specific fundraising drive for outreach?

Holy crap! That's appalling.

Which ones do you have in mind?

I think that the manuals that the patients received already built in considerable bias and that the kind of face-to-face pressure that you're talking about would be unnecessary icing on the cake, as far as needing to show that bias could account for the results. It was clear from the original...

This is true - it goes well beyond PACE (just as what's going on at the BMJ at the moment goes well beyond Esther Crawley's school absence study).

@dave30th - I wonder if it's worth contacting Richard Smith, former editor of the BMJ, to try to get an idea of what's what. He wrote a blog post pushing for release of the PACE trial data in the run-up to the tribunal.

I don't know how Goldacre's team broke down their analyses - I wonder if they looked at drug vs non-drug and academia vs pharma.

I think the proper downfall of PACE will take such an inquiry, since the authors and the host journals and the MRC will never admit fault and, as you say, there's no one else to abritrate. One might argue that NICE is already aware of the faults of PACE and that such an inquiry might be...

Is this true, though? What about all that work by Ben Goldacre's team (irony, irony) on outcome switching? It seems to be being done on a huge scale (and they're looking specifically at trials published in the top five medical journals): http://compare-trials.org/ I'm assuming a lot of those...

o_O

I'm also wondering why we'd be interested in what this guy says. He seems impervious both to fact and reason. According to his Twitter page: Medical doctor. Phd. History and Philosophy of Medicine. General practice. P4 medicine. Precision medicine. Some tweets in Norwegian, more and more in...

Hence Le Pétomane ('Fartomaniac'), the famous French flatulist. Though this probably wasn't the kind of thing you were thinking of.

Sorry, I didn't see the quote marks. o_O

Oops, you're right! Sorry, @Sly Saint!

I'm not sure I undertand your point, @Joel. A graph (though not even the summary numbers underlying it, refused in response to an FOI request) showing step-test performance was published in the Chalder et al. mediation paper. But you know that, so what am I...

That quote is from 2010, @Sly Saint - eight years ago. I think your use of the present tense is a bit of a stretch! :) What I'm interested in, and what this thread is about, is AfME's attitude to PACE right now, in 2018. Edit: Apologies, @Sly Saint! I thought this was the other thread. But my...