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There's a third option, mentioned by the authors, namely a lack of precision. The previous studies of this kind did find an effect for blinding when subjective outcomes were used and in the current study, the confidence intervals are wide, suggesting that other samples might find a clear effect...

Hmm, yes I could see the image posted. Tried something else - hope it works for you now.

We did a little better than last week. For a brief moment in time, we were more popular than love island in the UK.

It’s MEawarenesshour tonight at 8 PM London time. Hope you can all join us. Some patients counted the number of tweets per MEawarenesshour and it seems that we’re getting bigger and stronger every week. Hope to break a new record tonight!

He previously defended the PACE trial on Twitter, when the HRA-report came out.

Thought this was interesting.

Thanks @Dolphin !

Really? That's quite shocking, to be honest. Do you happen to have a link/source for this? I thought an exclusion had to be something that can explain the symptoms.

If fulfilment of three case definitions was a requirement to get a ME/CFS diagnosis in this study, we would also expect lower figures than previous prevalence estimates in adults where only fulfilment of the Fukuda criteria was required. Perhaps it's simply prevalence estimates can only give a...

Byron Hyde is not an author of the ICC but someone who is often referenced by patients who protest against the use of the term ME/CFS. I noticed that in the book Hyde edited in 1992, he repeatedly used the term M.E./CFS. The book is titled "The Clinical and Scientific Basis of Myalgic...

Thanks to Tom Kindlon for pointing this out. I've made a twitter thread on a related issue, as many patients who harshly disagree with the use of the term ME/CFS seem to be on twitter: Here's the full text (with numbering per argument rather than per tweet) "Here are some reasons why I still...

Yes, a couple of days ago they published a paper on the health-related quality of life of 400 patients seen in their clinic from 2014 to 2018. They write: "To be included in this study, participants were required to fulfil the Fukuda case definition."

I realize you're being sarcastic but in essence, I'm not asking for 'further info' but basic info about their methodology that probably should have been reported in the supplementary material of their paper. I think a paper should have sufficient information on how the results came about.

The supplementary material does give the total figures for each blinding assessment: Definitely no - 16 Definitely yes - 15 Probably no - 73 Probably yes - 18 Unclear – 10 The paper explains that the comparison was made between trials where blinding was assessed as Definitely yes and...

@Esther12 The authors of the BMJ study selected trials from each Cochrane review for their comparison, they didn't use all of them. They said they used 132 trials from these 18 Cochrane reviews but if you add up all the studies in these reviews you would come to a much large number. So it's...

Ok. Are there any epidemiological studies from before 1983 I should take a look at?

Any chance you could invite Sandra Pearson to have a look at this thread? Or does anyone else know smart Lyme advocates who know the literature well and might be interested in joining the discussion? I would be interested in hearing their thoughts.

Yes, thank you. But I'm mostly confused by the scores. The text says "the Lyme group had lower global health status scores compared with controls." But the table gives a mean and standard deviation of 23.8 (15.2) for the Lyme disease group and 18 (15.6) for the control group. Maybe it's just a...

I realize that this is a controversial issue and it's certainly not my intention to throw oil on a fire. I hoped that a focus solely on epidemiology would provide an interesting perspective because that seems to be the foundation of all else. I hope people will take no offence at the...

References [1] Rebman AW, Bechtold KT, Yang T, Mihm EA, Soloski MJ, Novak CB, et al. The Clinical, Symptom, and Quality-of-Life Characterization of a Well-Defined Group of Patients with Posttreatment Lyme Disease Syndrome. Front Med (Lausanne). 2017 Dec 14;4:224. [2] Shadick NA, Phillips CB...