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I usually compare it to the fatigue people have following a severe infection or a major surgery. It's not the sleepy-type of fatigue you get from staying awake for more than 24 hours, nor the tiredness you get from working really hard (which sometimes can be pleasant).

I think there's a difference. There'an argument that past definitions have focused too much on fatigue, that we don't have reliable diagnostic criteria to define the illness and that this creates uncertainty about diagnosis or heterogeneity in research samples, etc etc. So this is seen as a...

I would add something like: ME/CFS isn't being funded because many researchers think it's not an illness but a collection of disorders that have little in common except vague symptoms such as fatigue and a lack of a pathological explanation. So, in this case, it's not so much a problem of...

@strategist and @Trish Thanks. I've rewatched it and it seems that they simply mention an anecdote of a patient doing GET and having worsened values on CPET. The Belgian report had CPET info on patients who did GET and/or CBT with graded activity and the results were stable, rather than...

Who suggested that?

It's mostly that they tested a lot of markers for T-cell metabolism and most seemed normal. Will have to see if the abnormalities like glycolysis in CD8 cells can be confirmed by others...

I got the impression from reading the paper that metabolism in CD4 and CD8 cells is relatively normal.

The authors argue that medicine has "classificatory models" which "do not identify aetiology or any specific pathogenesis but rather describe collections of clinical phenomena that often occur together" like depression for example. Classificatory models may help in finding the underlying...

The (old) comment of mine you responded to was a little different though. It asked: "I would kindly want to ask whether Jeff or Jen could direct me to the scientific articles that do describe CCI as something that closely resembles ME/CFS." Looking for long lists of symptoms of both conditions...

I find it a bit weird that there wasn't any significant difference in symptoms between the high and normal lactate group, except for PEM. If it was important to the illness, wouldn't we see more difference between those two groups?

To be honest, I normally focus on psychosocial ME/CFS research, so I know very little about the specifics about blood draws and sample preparation. I think the hypothesis suggested by Theorell et al. is intriguing, so would be interested if someone with more knowledge can make sense of it.

I had a closer look at this review. It seems that for most outcomes the results were rather conflicting, with the sole exception of natural killer (NK) cell cytotoxicity. Cytotoxicity refers to the ability of NK cells to destroy cancer cells or virus-infected cells. In contrast to other...

I've posted this on Facebook. Feel free to point out mistakes so I can adjust them:

This is quite frustrating. If 100 people are planning to pay 300 pounds then in total 30.000 pounds are going to be spent on a clinical test that isn't properly validated. The Tomas et al. study suggested that initial positive results might have been due to the longer processing of ME/CFS...

Betsy Keller Speaks in Norway November 2019 As part of the Norwegian ME Association’s Knowledge Campaign 2019, Dr. Betsy Keller traveled to Norway to present on post-exertional malaise. The Norwegian ME Association has uploaded her talk to YouTube and can be watched using the embedded video...

It does sound familiar:

Sounds like great news.

Sorry to hear this @Sly Saint, that's horrible.

It's free, you can just click on the pdf: https://jnnp.bmj.com/content/jnnp/39/4/381.full.pdf

There's some background on the Zinns in this article: https://depaulmagazine.com/2019/03/14/the-myth-of-its-all-in-your-head/