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I know very little about this sort of biochemistry but choline seems to crop up everywhere.

Fascinating. What more can I say! The lipid shifts may be more than just confounding co-morbidities too, but I think these oddball findings like SOD3 and BCHE are easier places to start.

I think this is a key point. I don't think it is addressed in the paper and maybe some analysis should be made. I am travelling but hope to get some detailed comments down for Chris and co within a week or so. I think there are some major issues to sort out in relation to confounding...

It looks like ill-informed hype to me. Tagging an antibody to fibrinogen would just leave you bleeding. Tagging it to fibrin would likely make the inflammation worse. No serious scientist is going to come out with the sort of scattershot statements seen here.

I might fit but I wouldn't want to have anything to do with twitter/X I am afraid.

Yes, there are a range of conditions that will produce 'fatigue' this severe. Not many of them give intermittent symptoms this severe, but some can. It isn't really covered by specific research. It is just a reality of clinical documentation. In general, isolated question about diagnosis like...

Absolutely, but the claim seemed to be the inappropriate generalisation that psychiatric nurses behave terribly to all patients. Of course we want to root out the 'functional' paradigm. My point was that the problem was not that of being treated in a psychiatric unit but being treated in an...

I tend to agree with @Ravn about not needing a lot of background on ME/CFS, and also with @Hutan 's post (on the epidemiology thread) on sex ratio. Just as a technical point. My main concern about internet recruitment originally was that the GWAS might pick up an allele linked to behaviour that...

Copied post I tend to agree with @Ravn about not needing a lot of background on ME/CFS, and also with @Hutan 's post (on the epidemiology thread) on sex ratio. Just as a technical point. My main concern about internet recruitment originally was that the GWAS might pick up an allele linked to...

I agree, the comments quoted do not mean much. Since CRP is not raised in ME/CFS, for a kinase inhibitor to help you would I think need to have macrophage activation without involvement of the usual pathways involving IL-6 and TNF. That may be possible but one person feeling better after a few...

And what @TigerLilea said and the rest.

I think everyone has said it. There is no evidence. At least none that a worldly wise person should regard as reliable.

Well, I wrote my article specifically for the benefit of Sean O'Neil and it will have been seen by the Times journalists who wrote all the coverage, so I did do my best on that side!

I agree with a number of comments about the treatment of causation. I don't think the study can discount a 'psychosomatic' account because psychosomatic can imply that thinking modifies peripheral body functions in such a way as to cause symptoms and that may be biochemically mediated. In fact...

@Chris Ponting This looks interesting. I am about to spend a week speaking only Spanish so I may not be able to read through immediately! My initial thoughts: Nothing dramatic has turned up, but we knew that would be the case. And the point of the GWAS was that it had the power to force a...

It would be interesting to know what some of these molecular are.

I have done my best! And to be fair this came out at the recent inquest.

It happens all the time. I well remember a patient of mine with a spinal lymphoma who had just had surgery - aged about our age - who the nurses put on to 'TLC', which included not giving drinks or keeping her mouth clean such that on my ward round she was severely dehydrate. I said to the...

One thing I think we can be sure of is that there will be no NETs anywhere near brain endothelium in Long Covid. NETs are clumps of dead neutrophils outside the circulation in the tissue. If that was going on in the brain you would be on ITU with a tube in.

Thanks for the link. So, yes, the two cases seem very similar. Death was in essence due to neglect in the sense that feeding support should have been provided and was not. This would have been justified on the basis of a functional disoder ideology that says that people with ME/CFS have neither...