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I see it very often in patients of 10+ years, almost unheard of in patients of 3- years.

This is extremely common in long term ME patients. I sleep when I need to now, I live alone, but last time I had to regularly be up and about during the day, when I was studying biochemistry, my OI got very severe due to sleep deprivation. I lost count of how many times I collapsed in stairwells.

I currently regard cortisol as probably tending to low, but more importantly with a shifted timing of the cortisol response as a likely issue. Its far from big or certain enough to be a major issue though, at least in most of us. Now if the elevated beta cortisol receptor research will ever get...

I find the article linked to has confused arguments, glosses over things, and probably misses the point of science, evidence based medicine, etc., at least in this one article. I have not read other articles in the series, so maybe things are clarified elsewhere. Many anti-psychiatry arguments...

I would like to add that both articles suggest low blood volume is part of the OI component of ME, and is a common finding in OI.

See also this paper - https://www.researchgate.net/publication/260023072_Renin-aldosterone_paradox_in_patients_with_myalgic_encephalomyelitis_and_orthostatic_intolerance There are two other related papers on Research Gate by the same author.

It didn't take long ... and I will be citing Streeton and Bell. http://www.name-us.org/ResearchPages/ResearchArticlesAbstracts/CirculatoryArticles/BellCirculatingBloodVolume.pdf ABSTRACT. Chronic fatigue syndrome (CFS) is an illness associated with severe activity limitation and a...

I will run a search and hope to get back to you. Low blood volume is known in individual patients who have been tested for it, I am not sure its been the subject of a formal study, at least in the context of ME. In the general literature its called hypovolemia, which I am sure you are aware of...

Yes, but most docs don't order this test or even think to do it.

Low blood volume is in the medical literature but very few docs seem to know about it. Dosing with extra water might help correct the issue so that blood counts are closer to the actual numbers. However the inverse is true too ... taking too much water might alter other test readings. Its hard...

Open Office is something on my todo list. :facepalm:

I want to comment on this specifically ... I think some patients with ME might be anaemic and it NOT show up on full blood count. This is because a full blood count is based on concentration of cells. That is, the number per unit volume. The problem in ME is that many of us have lower blood...

Not just in the UK!

Actually predates this by 8 years ... McEvedy, and Beard.

You can easily find out. Create a survey to hand to the psychologists that asks them what they think about it.

I had this done in 1993, using two different methods. The first is gas analysis, which I keep pushing, though you also need to have a controlled or measured diet to find out what is being consumed. The second was for the brain, and was a tagged glucose scan. I did badly on both, and that was...

I had said that before, and suggested a gas analysis without exercise might tell us a lot. Metabolic function is most probably badly compromised at that end of severity.

I bet the immune system is exerting itself like crazy. It does not have to be muscle exertion.

This appears to be mostly an artefact of history, post 1988.

Yes. A well managed patient might be much sicker but have no PEM, purely from good pacing or other strategies.