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Temperature control is hypothalamic but I am not sure it is autonomic. The response of the hypothalamus involves things like changing thyroid hormone secretion and shivering (which is somatic rather than autonomic). Orthostatic intolerance is often attributed to autonomic dysfunction but there...

Was thinking of a randomly chosen cohort, to see whether the incidence of sensory symptoms in ME could be considered more than one would find by chance in a random selection of people. If not there would be no reason to think it was part of the ME.

A little rhyming, or not, goes a long way from Eire to Japan.

There should be but I am not sure there is. When Ramsay talked of fatiguability he was obviously noting a real symptom. However, my understanding is that electrophysiological studies do not demonstrate nerve of muscle impairment. The closest thing that I can think of that might explain what is...

797 or 0.8% I wish Estate Agents would charge as little as that.

It just struck me that it would be interesting to know how psychotherapists get on in a culture that believes in fate. I do not want anything I say to be taken judgmentally but what about those who believe that everything is the will of Allah? Or those who drive far too fast with a crucifix...

I think this is misconceived and tends to take things in the wrong direction. It is this sort of analysis that makes me think we should stop referring to 'outbreaks of ME' documented in the past, because they probably tell us nothing important about the illness people suffer from today. The...

Yes, I am afraid her list of calling outs looks pretty tame to me. And where it counts, off target.

I will be seeing them next week.

Yes, I am pretty sure the original application period was the same as for lay members. It looks a bit as if they have had no takers. Luis Nacul would be a good person to be involved. Or indeed Caroline Kingdon, the research nurse specliaist at LSHTM

Paul Dieppe used to be a quality biomedical scientist and was a close friend of mine in the 1970s. He was a hostage in Kuwait in 1990. Some time after that - maybe 1994, he asked me if I was interested in his chair in Bristol as he was moving into administration. I think something major had...

Do we know why Dieppe retired? He should have known there were problems from the outset.

Yes, it is complicated. I am being a bit unfair @Woolie, because I have recently published something in Frontiers in Psychology on the structure of mental representations. (https://www.ucl.ac.uk/jonathan-edwards/publications/distinguishingrepresentations.pdf) I think we can be fairly sure that...

This is clearly not the case, would you agree? My thoughts do not involve language at all in general.

So this rather tells the lie to the claim by psychiatrists that most patients love their doctors and their therapists and the people who cause trouble are a tiny fringe minority of nutcases. It seems that they are expecting quite a lot of patients to be dissatisfied with the behaviour of their...

Part of the problem seems to be that anyone with an acute febrile illness in the hospital and a whiff of some neurological symptoms got put down as one of the outbreak cohort. But the impression from McE and B I got was that of the rather few cases with symptoms that might have been interpreted...

I appreciate your fervour @Mithriel, but I think it is important to take the evidence on its merits. As someone trained in neurology I recognise the analysis McE and B make as in line with reliable practice. In contrast, Ramsay's account is vague and pretty implausible at times. To describe so...

But which is the 'commonly accepted wisdom'? The relevance of the outbreaks for me is that they distract from a useful scientific discussion of ME as it affects hundreds of thousands of people today and thereby distract from useful advocacy. My feeling is that if ME advocacy literature refers...

I was assuming people would assume the choice was 1-9! It could have been 1-100. The conclusion remains the same!

I suspect McE and B did not think these were worth commenting on because they would simply suggest that the subjects had a viral illness, as hospital workers are likely to several times a year. I think they were suggesting that the evidence for an encephalomyelitis may have been explained by...