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This seems like a very compelling study. It's honestly one of the most exciting papers I've read because it provides strong support for a very specific lead. The study found a strong gene-environment (GxE) interaction between exposure to sarin gas and the PON1 Q192R allele, which is known to...

Health Rising: 'Is the OMF’s ME/CFS BioQuest Study the Study We’ve All Been Waiting For?' Article includes an interview with OMF's Danielle Meadows.

There's a comment, but the details are behind a paywall: Comment on “Association of Symptoms of neuropsychological long COVID with imaging and plasma biomarkers” Shukla, Ankita; Brahma, Pratyush Kumar; Rajput, Dharmendra Singh Web | DOI | Journal of the Neurological Sciences

Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers Highlights • Neuropsychological long COVID i.e. “brain fog” were investigated by biomarkers. • Cognitive impairments related to abnormal rCBF in the occipital lobe. • Psychological symptoms related to...

Another resource that helped me understand: The Intuition Behind Confidence Intervals

Distinguishing post-COVID from long-COVID in adults: Development and validation of a biomarker signature using targeted proteomics and machine learning in a cross-sectional observational study Background COVID-19 can have diverse clinical manifestations, ranging from asymptomatic infection to...

Some discussion about antivirals has been moved to: Antivirals as ME/CFS or Long Covid treatments (e.g. valacyclovir, valgancyclovir, amantadine)

Very cool. I notice that the link you provided seems to already have a DecodeME custom track with variants.

Auto-translated section mentioning genetics, with bolding added:

Hi @nafione, welcome. We have a thread for that study: Evaluation of a Gene–Environment Interaction of PON1 and Low-Level Nerve Agent Exposure with Gulf War Illness..., 2022, Haley et al But it looks like most of the discussion for that study was on the general gulf war illness thread: Gulf...

Now published: Web | DOI | PDF

This is unclear. What does it mean for physicians to be in "contact with clinical problems that can inform ME/CFS care"? Add comma before "off-label" Add comma after "ME/CFS" Agreed. This part stood out as the easiest to misunderstand. I think it should just say or summarize the advice right...

Posts about a GLP-1 related anecdote have been moved to: Ozempic, tirzepatide and other GLP-1RAs - impact on ME/CFS

Acute inflammation and fronto-striatal connectivity in the transition from acute to persistent fatigue after mild COVID-19: A longitudinal fMRI study Background Persistent fatigue is one of the most common and disabling sequelae of COVID-19, yet its neurobiological mechanisms remain poorly...

Why does figure 12C differ from 12A, in terms of CD3 distribution? In 12A, there's a cluster around the 0 mark on the y-axis. But there's no cluster there in 12C.

This study is helpful because they compiled transcriptomics and proteomics results from several studies into one file, Supplementary File S2. It makes it easier to cross-check expression findings in older studies in the future. For example, here are the differentially expressed proteins for...

This paper seems to show the same data for CFS, but without the inclusion of autism data: NeuroSPECT Findings in Children with Chronic Fatigue Syndrome Goldberg, Michael J.; Mena, Ismael; Darcourt, Jacques Abstract Background NeuroSPECT studies have described specific abnormalities in...

It's hard to tell which parts of this are based on significance testing and which are just saying the direction of effect. For example: They looked at 10 genes that were significant in a previous study. Of the 8 genes that were also detected here, they reported downregulation and upregulation...

Some selected quotes from the treatment section: This is the review he cited as evidence for this slide (link goes to S4ME thread): Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review (2019. MDPI Diagnostics. Rivera, Lidbury, et al.)

Sanil Rege has a YouTube channel with 160k subscribers. Here are some of his videos on ME/CFS: Chronic Fatigue Syndrome and ME Simplified - How to Diagnose and Treat CFS | A Psychiatrist Explains The Hidden Link in Chronic Fatigue, Long Covid, and POTS: A Deep Dive into the Role of the Brain...