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So neurons in the brain and nervous system respond to immune signals from cells in tissue - like maybe bone marrow - and those signals affect the signalling the neurons do in the brain - theoretically turning on sickness behavior etc?

Could you explain this part for the more brain fogged among us (i.e. me!) This discussion is really interesting but I dont quite follow this bit.

I haven't heard of them being tried - i dont know much about them, could you explain their relevance to this paper?

No because you see, our magic brains made us sick because we were doing life all wrong and so all these people needed to be paid the big bucks to teach us to go for a walk in nature and have a chat with our families and maybe do some sit ups. We could never have thought of this on our own. So...

Hopefully it will cause a great deal of harm to the authors reputations when the science comes through for us. This is all going to look as utterly indefensible as it really is. Unfortunately in the meantime it will get pwME and LC sectioned and forced into harmful 'therapies'

That's disappointing but it sort of makes sense, thanks.

Perhaps some of the bright minds on here might be able to make something of it!

Or they never find it, because antidepressants dont work for anywhere close to everyone and therapy isn't enough.

This is definitely part of it - to shut people out of medicine, but it also provides a neat story for doctors, insurers, NHS providers etc about why they are shunning the nasty heartsink patients. Its not that we dont understand whats wrong with them, its that they're bad and dont want to get...

I actually think that drawing comparisons between Eysenck and the work of the MECFS psychobehaviouralists might be a good way of highlighting how empty and fraudulent it is.

There was a researcher at Kings College London who made his name on just this sort of thing - Hans Eyesik, something like that. Was later found to have committed fraud in his papers. All sort of 'a certain type of person gets/dies from cancer' - negative people, anxious people etc.

I have no idea but it would be incredibly funny if it wasn't so deeply destructive and frightening. These people think they are doing science. They think this parade of woo nonsense and reheated Freudianism is good science. And apparently so do the people that fund them.

This paper is going to cause harm.

I've seen reports of people made a lot worse from Pemgarda too. I think at a certain point these researchers need to see the writing on the wall and pivot. But not towards the placebo effect :banghead:

Yeah you feel like quoting mean girls at them 'Stop trying to make viral persistance happen'

It does seem ambitious but given how quickly fluge and mella got going on dara p2 perhaps not impossible.

Yeah this is disappointing and bizarre

Because they haven't wasted enough time looking for what almost certainly isn't there.

One of these days, one of these studies will live up to the hype. Well, I guess it probably won't be hyped up by The Twitterati feat ChatGPT, but it will actually show something major.

Heres some talk about OLFM4 in this context