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What do you mean? Don’t you know all you need to do is imagine and visualise something and you can manifest it into being? /es (extreme sarcasm)

Thanks @Hutan Sorry I’ve been scattering stuff in different threads as I’ve been learning, I linked this elsewhere but it is a good video on the general topic of regulation of transcription. The whole module is worthwhile too or there’s a written summary here.

I like this comparison. It highlights the absurdity but also reminds me of the patronising approach some have to poverty ’oh have you tried budgeting’ or ‘well if you didn’t spend on x’ which completely ignores the various ways in which real poverty completely removes choice, the ability to do...

Thanks @jnmaciuch and thanks for the all the pointers. Yeah SOX6 definitely seems relevant, it is hit and many of the locations of these promotors and enhancers for other genes which are hits are also hits. It’s just possibly not quite as uniquely unifying of everything than I thought it could be.

Focusing on local services is probably what I’d do. For a local political party the council may therefore be a good focus, especially with their responsibility for social care. I’m not sure what the precise asks would be but focusing on the situation of severely affected and abandonment by GPs...

Me either, there seems to be discussion in this thread but a blog or summary would be useful if anyone can point to one https://www.s4me.info/threads/invisible-illness-a-history-from-hysteria-to-long-covid-2026-mendenhall-book.44402/

Short version: It looks like this is may not be as significant as I initially hoped. SOX6 seems to be everywhere! Longer details: Maybe this is because it is a common transcription factor or perhaps a bias in the computed data on binding sites? Either way, it may still be useful information...

I have never been happier that I block all dns lookups to twitter!

Interesting! Nice charts. I’ll try and use this gene set in the testing of SOX6 binding sites that @jnmaciuch mentioned here too. It could be another interesting comparison…

Seeing all these various bits of woo rich people are spending a fortune on I think we should set up something (maybe we can say it’s using the ‘wisdom of chronic illness’) and sell it for loads to fund the proper research we need.

Funny you should mention that… :) Good suggestion on the conditions thanks, I was thinking of comparing to a random selection or another GWAS set when I’m up to it, but hadn’t thought of looking at more brain related conditions, makes sense! Any thoughts on this? It sort of feels intuitively...

It’s a good idea. I think that’s what I was trying to describe with the difficulty knowing what is signal and noise. Everything is significant when I first spot something and dig into it :) And I don’t really know enough or have the experience to be able to discern.. There’s a common cycle of...

Are the right people seeing it? A bunch of us are prodding at things and asking questions, but can only take things so far and I think largely hope something worthwhile crops up piques the interest of some researchers who can do something with it. It can be difficult to know what is signal and...

Agree and while I very much appreciate some the kind comments but that’s all I’m doing. From bed with an iPad and nothing more than a GCSE in biology. The science is sometimes an escape for me too tbh. It’s tragic that those who should be supporting us aren’t but it is great so many patients...

Another one for the nice things are nice list? I’d be happy to have social prescribing of chocolate given the rise in price of my usual bar of dark Belgian chocolate over the last couple of years!

A webpage (because it was too long for a post) with details from genehancer of all promotors are enhancers for DecodeME candidate genes which mention SOX6 as a transcription factor binding site. Included are links to the locus in the DecodeME data and genehancer sources with info on tissues/etc...

I guess so, they would also all need to be pointing in the same direction to magnify, with all the permutations I can see it being just as likely that a change in one cancels out a change in another. It does though seem significant that SOX6 shows up in the binding sites of potential promoters...

Sorry this may be going off topic and getting fragmented, but I’ve been through all of these files to check for mentions of other genes in original candidate gene list to answer the question: Which genes in the decodeme candidate gene list are mentioned in potential binding sites for other...

Genecards info The NCBI summary And from the UniProt summary There’s various studies, mainly mouse though, mentioned on OMIM around oligodendrocyte development in mouse spinal cord, selectively expression in distinct subpopulations of mouse embryonic and adult midbrain dopamine (mDA)...

Of the genes in that list for this study 4 are in the 59 gene DecodeME set: CA10, DCC, MLLT10, SOX6 And 3 in the 259 gene PrecisionLife anakysis of DecodeME set: CTNNA2, DCC, UTRN