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Migraine can cause light sensitivity. Also, some ingested drugs can cause the pupils to dilate, which I would assume would cause light sensitivity similar to the topical dilation you'd receive from an optometrist in a retinal exam. So, there'd be at least two possible mechanisms for light...

So... could mycotoxin producing fungi in the gut be a source of constant exposure? I know Ian Lipkin has mentioned looking into booth fungi and viruses in the microbiome, in addition to bacteria.

From "something in the blood" ?

Does the paper address how this impairment in Complex V could happen in enough mitochondria / cells simultaneously to account for the "sudden" onset often seen in the illness? It seems like some sort of exposure to a system wide "trigger" would be needed (or some kind of signaling in response...

Should we alert the BMJ? They may want to publish these findings. ;)

From the Guardian article: From David's repsonse on Virology Blog: I think David is being too generous here. Most people would probably take a construction like "a man called David Tuller" as a way of implying that David has no credentials (other than being a "tough kind of activist" and...

I had been diagnosed with nystagmus several months prior to all these tests. An internist noted it a couple of weeks after onset. It's possible that I just don't remember a spinning reaction to the caloric test, or it might have been less noticeable to me sitting in the dark. I'm also not sure...

Let's see... bio-feedback, 2 months of psychotherapy (until I showed up with my vestibular results and was "fired"), half a year of multiple, self-injections for food and pollen allergies on alternate days, rotation diet, eye-exercises, niacin therapy, several 24 hour holter monitors... none of...

Lol! Actually, were my dizziness still like what it was in the 1980's, I probably would have already gone. It's safe to say I've tried weirder things.

I'd been on trains, planes, boats, amusement park rides, etc... prior to ME and never developed anything more than temporary unsteadiness, but ME began for me with an "out of the blue" attack of dizziness that seemed like it was it was going to resolve in a few days, but then got worse again and...

A few years back, I took and overnight train ride and was surprised at how "dizzy" (the "bobbing" back and forth feeling) I was when I got off they train. It was like I was back to where I was 15 years earlier. I'm not sure if it was the motion of the train or the change in altitude over a...

This sounds a lot like what happened to me: post viral onset, intense dizziness for several years, which improved maybe 50% over a period of months in the fourth year. Then the rate of improvement plummeted, but not to zero. It took 10-15 years for most of the remaining dizziness to abate. I no...

I'd say there's no question that compensating for a balance disorder requires a lot of mental energy and that that can become exhausting. It also requires a lot of conscious attention which means there's not much left over for other things, especially when you're on your feet and in motion. My...

I don't know about this. Even self-proclaimed history of fatigue expert Edward Shorter has written that the diagnosis of neurasthenia had become rare by WWI, and was virtually gone by WWII. This 1984 article appeared in the New York Times: HYSTERIA WAS FOR WOMEN, NEURASTHENIA FOR MEN...

Interesting. I haven't heard of this before. If a patient were fed intravenously (paraenteral feeding), I could see the gut microbiome being so starved of nutrition that it eventually "disappears." In enteral tube feeding, on the other hand, nutrients are still delivered to the gut, so I'd be...

I think it took more than a decade after the discovery of h. pylori and its role in peptic ulcers was recognized (in 1982) for there to be an official recommendation to treat the bacteria (and the disease) with antibiotics. Fortunately, they got around to it before Marshall and Warren were...

Oh, good! That college philosophy course is about to finally pay off!

A possibility I wonder about is if something in the microbiome could be producing a molecule that gets into the blood and causes havoc. Some post-infectious change in the balance of the microbiome might favor an organism that normally produces an innocuous amount of this molecule. Subsequent...

It's hilarious that the following description is apparently intended to raise eyebrows about David Tuller: It reminds me of a line from an old episode of "Get Smart" in which Max is on trial... Maxwell Smart : "Now it's easy for the prosecuting attorney to stand up here and accuse me of all...

My dizziness seems to be unrelated to PEM. It was at it's worst in the first 4-5 years following onset and then gradually (and I mean gradually) has improved improved since then.