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Titles of sections: 1. Introduction 2. Acute COVID-19 and the emergence of persistent illness 3. Patient narratives and early recognition 4. Patient support groups and digital communities 5. Naming Long COVID 6. Medical gaslighting in the context of Long COVID 7. Patient voices in treatment and...

“Long COVID”: The First Illness in History Named by Patients Mari Shiozaki Abstract The COVID‑19 pandemic created a large population of individuals who continued to experience debilitating symptoms long after the acute infection had resolved. This chapter examines the emergence of Long COVID...

Pathogen Effector Convergence Theory (PECT): A Protocol to Create a Unifying Framework for Post-Acute Infection Syndromes (PAISs) Jain, Nita Abstract Post-infectious syndromes (ME/CFS, Long COVID, PTLDS) represent significant global health challenges with overlapping clinical manifestations...

High prevalence of obstructive sleep apnea in patients with Long-COVID. Background Long-COVID (LC) is defined as the persistence of symptoms 12 weeks after the acute COVID infection not explained by any other alternative diagnosis. Its pathophysiology is poorly understood. Obstructive Sleep...

I would say this is still a little inaccurate. DecodeME didn't find differences in genes, they found differences in genetic variants. As far as I can tell, the mapping of these variants to immune or nervous system genes is still very speculative. The other two main findings are the MAGMA...

They saw basically the same pattern in the idiopathic chronic fatigue group, so I think probably not just chance: Maybe just that more viral infections happen in the winter.

From paper:

Sex Differences in Long COVID Prevalence Over One year After the Acute Phase, and Related Risk Factors. The GINA-COVID Cohort Study Background This 1-year cohort study aimed to track long COVID prevalence, identify associated risk factors, and assess its association with hospitalization...

The efficacy of exercise in patients with myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and meta-analysis Zhao, Liping; Gou, Bo; Zhang, Meng Objective To evaluate the efficacy of exercise training for patients with myalgic encephalomyelitis/chronic fatigue syndrome...

I don't see anything that suggests 23andMe would report a thymine when there is no thymine. And contrary to what DonnellanP just said: That page looks like evidence that they do expect individuals to go through their DNA and look at their alleles.

Based on zero evidence presented by you, despite several requests to understand why you are saying this.

I have continued searching for terms that are highly correlated to search interest for "chronic fatigue syndrome" at the metro level, using the program I used before (with some alterations for finding better related terms to test, such as having an AI suggest related terms). I actually...

Just adding a link to a thread for the study: Sex effects on gene expression across the human cerebral cortex at cell type resolution 2026 DeCasien et al

Here are links to some of them: General discussions Migraines caused by ME - How to discuss with Neuro? Migraine treatments Are there symptoms you had in the early stages of ME that you no longer get? - Some =477&o=date']mentions of migraine Why has 'persistent enteroviral infection' been...

Genetic correlation A recent preprint found a genetic correlation of rg=0.45 between ME/CFS (DecodeME) and a USA migraine cohort. This figure is similar to the genetic correlation value I found when testing correlation of DecodeME with other migraine cohorts (UK BioBank and FinnGen). Insights...

I thought it'd be good to have a public thread for general discussion about how ME/CFS and migraines may be related. We have a members only thread for sharing experiences as well. Mainly, I want to link relevant discussions happening on various threads, so they don't eventually get buried.

The following study is actually about incidence rate, and brings the second peak in line with the figures for the second ME/CFS incidence peak. The first peak is a bit later than in ME/CFS, though. Another study for incidence rate peaks. It's a small (n=75) study, only on those with Von...

Oh, actually, this is comparing incidence peaks in ME/CFS to prevalence peaks in migraine. I think prevalence would be expected to peak later, though I'm not sure how much later. So maybe the ages of the migraine peaks are closer to ME/CFS than it seems from this.

The first MAGMA plot above is for 54 specific tissues. For the more general tissue grouping, there were two significant tissues showing enrichment of GWAS genes, both in the full cohort, and in the men-only cohort: brain and uterus. Here is the plot for men: This is interesting, because males...

They did a lot of comparing their findings to a previous migraine GWAS: New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis (2021, Communications Biology) I took a look at that paper, and interestingly, in the MAGMA analysis in that study...