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Yep, that's exactly why I'm asking.

I think it may be partly related to the lack of official diagnosis, i.e. people don't even know that they have it or an uncertainty even among the diagnosed patients that this is their disease and that this is what's gonna be researched by particular foundation/charity that hey choose to donate...

I'm wondering if there is any study or anecdotal evidence of POTS patients undergoing 2-day CPET?

Absolutely. I'm not discounting the possibilities that you have mentioned and they're always in the back of my mind. I wasn't very clear in my post that I don't think that SIBO or the microbiome is the underlying problem. That was my wishful thinking 3-4 years ago. I think at that time I just...

This is what seems to make the most sense to myself and how I experience symptoms. Do you think it's possible that for whatever reason the immune system gets primed against commensal bacteria in the gut and looses tolerance? I think I have seen some studies on immune reaction to microbiome in...

I think there is a general trend in psychiatry to think that mental illness has to start in the brain, whether it's psychosocial or neuroinflammation. It's much more likely that at least some part of depression/anxiety comes from low grade inflammation in the gut, which affects the brain, but as...

Fwiw, it seems to help in fibro, so maybe there's something to it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328426/

Really? And where is that STRONG evidence?? I doubt you would see Sharpes and Weasels using that type of unjustified rhetoric in a scientific article, because they know that it's BS, but this is a book, so I guess you can do whatever you want if you follow the BPS logic. And guess where most...

O think it's similar to celecoxib, which is available in US. May I ask why are you interested in it?

In the beginning of my problems I highly suspected that SIBO was the underlying problem for all my symptoms, probably because I felt that there is a very strong connection between what I eat and how I feel, and the fact that starving bacteria(all meat diet) for a day or two would kinda like push...

I agree, especially, given that many people who comment on reddit, etc are actually saying that Jamison is the most legitimate patient and some even know that ME/CFS is a real and serious condition. No need to make ourselves look crazy by fighting something that we don't necessarily need to.

I think the question asked was inappropriate. "Has your ME/CFS progressed from when it began?" I think many people would answer yes to this question, because it's not uncommon to try and push through and then get worse, but not necessarily because the disease is progressive in itself. The more...

I looked at it again and the direct quote is: "We did find one drug that seems to improve ATP production and that is a drug called Ativan. I know that it helps because we've given it to my son" That was in response to someone asking about using the nanoneedle device to test for drugs.

Makes sense, because it's also an SNRI, and SNRIs I think are sometimes mentioned in the context of POTS, since they can increase norepinephrine.

This is a very good question. I think we may come up with a few potential explanations. I've just recently finished watching the DVD of a recent IiME conference where Ron said that Ativan does something to ATP, probably increases it, although I don't remember exactly, so that's one. Another...

We don't and it shouldn't be there. Afaik, there are no studies looking at mast cell activation in ME(except one, maybe), although there should be. Having mast cell symptoms doesn't mean that it's MCAD. Mast cells are constantly reacting to the environment so it wouldn't be surprising that they...

SIBO is not a disease in itself. It all depends on what is causing it. There are LOTS of possibilities.. Rifaximin and metronidazole/neomycim are usually used alone or in combimatiom depending on the type of gas present. Funny thing is that my last step to ME/CFS was actually probiotics, which...

Or maybe just a part of ME? I think there haven't been any good studied on muscle biopsies to say that this is not common. I'm guessing that we'll be surprised with the number of abnormalities found when doctors start looking at the right places.

Unfortunately, you're probably right. Despite the fact that they obviously have reviewed much of the important literature, they have some trouble connecting the dots.. E.g., this paragraph appears to be self-contradictory and not much better than some psychobabble we all have seen before..: I...

Thank you!