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I'm not sure what is happening in this case but in some cases of microfluidics you either move a droplet around (via activating electrodes) or you have a flow through something like a capillary action to move a small amount of fluid into a chamber for testing. Then you can measure things like...

Yes I think I just made my point badly. I was just trying to say that the experiment and what it suggests is interesting rather than whether it is a biomarker.

There is data here in terms of things like work hours missed by parents that I don't think has been reported. Here are a few graphs showing the number of work hours missed by parents (carer 1 + carer2) at the various measurement points. But there is a lot of missing data

Correlations between the different variables may be interesting. I've done some simple plots to show correlation on the non-economic data. Note I've failed to add a title so the first image is for LP and the second for SMC I'm not sure what to make of them but it looks like the SMC is what you...

I tend to think this work is less interesting as a biomarker but as a demonstration that something changes when a cell is put under stress and its probably more important when they publish the plasma switch results. In this way the work hints that there is a change in something in a cells...

Here are some graphs looking at how school attendance (self reported) changes between different time points

I did wonder if someone else could replicate with a different microfluidic chip that measures impedance. There seems to be quite a bit of research in this area although its not using nano scale engineering. I'm not sure if what they are doing with impedance matches with what others are doing though.

There does seem to be quite a lot of work on impedance spectroscopy and its use in micro fluidics devices most of it seems to be applied to looking at different chemicals or flows of stuff rather than biological analysis. So I assume there is a solid background behind what Ron is doing with his...

Sometimes I wonder if there is confusion about CBT here. As I see it CBT is about getting people to 'challenge unhelpful thoughts' but the thoughts that are chosen and targeted would be dependant on what CBT is trying to tackle. Hence with CBT aimed at ME they may not even aim at depression and...

I think I did the same with stuff for a walk in shower. I have a vague memory of claiming VAT back for a adjustable bed but not sure. Its worth people being aware of the possibility though.

I think if you are in the UK and buy an adjustable bed or reclining chair (maybe just a rise and recline chair) for disability reasons then you can claim back the VAT paid. I'm not sure of the process but here is a link...

It does make me wonder which areas she was in charge of as the deputy editor and how these relate to the issues that have been raised with Cochrane.

The motivated intruder is a standard test applied by the ICO but I think it assumes no illegal action (otherwise the data could just be obtained anyway - especially given universities IT security is often quite poor).

I thought @Carolyn Wilshire covered some of these issues in her paper https://www.researchgate.net/publication/283476227_Psychogenic_explanations_of_physical_illness_Time_to_examine_the_evidence

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I guess someone could do some testing with comparing CK with activity monitors to see how well they map (with PwME and others).

The questions really matter here as well in terms of knowing what people were asked and how much they measure perception rather than actual things.

It seems to have the same issues as PACE in terms of subjective outcomes. Not only do they not learn that such approaches don't give reliable results but the NIHR who fund the trials equally don't seem to get the point (or allow reviewers to be chosen who run equally poor trials). As academics...

That was why I was thinking researchers could partner with a patient forum to help understand the area, the useful questions and issues and how to recruit along with the issues for patients in taking part in any form of focus groups (on line or not)

Any thoughts on finding some friendly academics that we could work with through the forum here to link with and get patient views?