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Maybe there's a better thread for this, but there's a post on the MadeMeSmile subreddit from a musician in Austria called Sebass: I am 24 and finally getting better. I have been chronically ill and mostly bedbound for 2 years with a very unknown disease. Making music from my bed has taken off...

That sounds interesting. I don't think I recall discussion about how ME/CFS may be caused by antibodies specifically from EBV infected B cells, or what that could mean.

Interpreting hand grip strength in hospital employees with post-COVID syndrome compared to non-infected controls: a case-control study Abstract Post-COVID syndrome (PCS) is characterized by a variety of persistent symptoms following SARS-CoV-2 infection, including fatigue among others...

I'm currently reading papers about CA10, and came across this one that seems kind of odd. I thought it was worth checking if there are real issues here, as findings related to CA10 could be important, considering CA10 was a DecodeME gene. In 337 participants with osteoporosis, they tested for...

Nucleotide variations in genes encoding carbonic anhydrase 8 and 10 associated with femoral bone mineral density in Japanese female with osteoporosis Abstract Osteoporosis is a multi-factorial common disease, which is caused by combination of genetic as well as environmental factors. Among...

Just undergone, or benefitted from immunoadsorption? If it's the latter, it seems like that could lead to some selection of the few participants who actually have an autoimmune disease. In a large enough group of people with ME/CFS, there will probably be a few people who also have an...

Some posts discussing preliminary results of Luis Nacul's trial of LDN have been moved to: Trial registration: Low-dose Naltrexone for Post-COVID Fatigue Syndrome, 2022, Luis Nacul, British Columbia Women's Hospital & Health Centre

Can it be that GDF15 is the body's antidote to weakness and frailty, and it being higher is not showing that it is a cause of weakness, but rather an attempt to compensate for the weakness?

The main finding was the TPPP region. There doesn't appear to be an association with either of the above TPPP SNPs in DecodeME:

See thread: Low-Dose Naltrexone: What is the Evidence? A Narrative Review, 2026, Gouda

Yeah, it's possible that a far away DecodeME variant affects TRPM3, but I don't think we have any data to support that currently.

I'm not totally sure if I understand your question, but I can't think of how it would tell us that. For the PheWAS lookups, I was checking what other traits were also significantly associated with SNPs that were significant in DecodeME. So if a TRPM3 SNP was significant, we could check if other...

As far as the actual findings of that study, SNPs in TRPM3 were most significant out of all the TRP gene SNPs they tested. However, it looks like there may be an issue with lack of multiple test correction, as discussed for another very similar study from their lab...

Maybe a few more genes to consider that were near the top for significance here: CDK5RAP1, based on the synonymous variant model, was the 18th most significant unique gene (if including South Asian ancestry results as well as the synonymous gene collapsing model. For the synonymous model, the...

There's a PubPeer comment for the preprint:

Thanks a lot for posting to correct the record, @DonnellanP.

Some posts have been moved to: Alcohol Intolerance poll.

Ok, I looked at how elevation correlates to ME/CFS search interest. Here are the highest and lowest elevation metro areas based on population weighted average of counties in the metro areas: Here is the plot using the simple average (R²=0.15): Here is the plot if using the weighted...

I think they put out new papers every so often when they re-analyze with more participants. This looks like the most recent version: Whole-genome sequencing of 490,640 UK Biobank participants Web | DOI | PMC | PDF | Aug 2025 | Nature | Open Access

The AstraZeneca study used the entire UK BioBank and all the hundreds of phenotypes it contains, so they didn't specifically focus on ME/CFS.