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  1. Forbin

    Top 10 scientific publications in ME/CFS over the last 10 years based on number of citations [Tweet by Dr Mark Gutheridge]

    Maybe the lower number of citations attributed to biological research is just an indication of the relative difficulty of conducting and publishing such research. Biological research often requires carrying out hundreds, if not thousands, of complex and sensitive experiments that involve...
  2. Forbin

    Erythrocyte Deformability As a Potential Biomarker for Chronic Fatigue Syndrome, Davis et al (2018)

    Thanks! For some reason, I thought the original article was an "abstract" and that the full paper was either behind a paywall or had been embargoed all this time. As you pointed out, the original article looks like it appeared in the "proceedings" of a blood conference. I wonder if this was an...
  3. Forbin

    Erythrocyte Deformability As a Potential Biomarker for Chronic Fatigue Syndrome, Davis et al (2018)

    Any idea why this has a different title, is in a different journal and has one less author than before? The text is also different, though it covers the same ground. Was the original merely an "article," while this is the "paper?"
  4. Forbin

    Signs of Hypoxia - anyone had this?

    A couple of years after onset, I had a couple of doctors (gastroenterologists at UCLA) take note of the color of my fingernail beds and ponder their significance. I think my nail beds are somewhat darker and more deeply colored than usual (and perhaps slightly tinged blue). To me, it seems...
  5. Forbin

    David Tuller: Trial By Error: “Talk is Cheap,” Patients Tell NIH

    My impression is that, if we want to get significantly greater funding in the U.S. than we currently have, then the most effective way to get it is through the political means of lobbying the U.S. Congress. Francis Collins clearly has influence over some discretionary funding - and I appreciate...
  6. Forbin

    The two age peaks in onset of ME/CFS

    Maybe the peaks represent the time when you're most likely to be exposed to some virus that provokes a strong immune response. The early peak might represent when you're in school, while the later one represents when your children are bringing home viruses from school. [The early peak around...
  7. Forbin

    Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

    FWIW, in the late 1980's I saw a PBS documentary about initial attempts to use interferon as an experimental treatment for cancer. Not long after the infusion, the patient experienced an episode of prolonged, uncontrollable shaking, like you'd get if you were severely cold. It's called "rigor"...
  8. Forbin

    Erythrocyte Deformability As a Potential Biomarker for Chronic Fatigue Syndrome, Davis et al (2018)

    It does seem like this would have been reported previously if it was visible on a routine test. Maybe this is something seen only after the cells exit a narrow channel like a capillary. If the cells are relatively inelastic, perhaps they retain their compressed shape longer after squeezing...
  9. Forbin

    Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

    It seems from the video of Professor Pariante's talk back in October that IL-6 and IL-10 were already a bit elevated in the patients who went on to develop persistent fatigue, even before they started taking interferon alpha. He draws attention to the fact the the levels of IL-6 and IL-10...
  10. Forbin

    Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

    It seems like these findings were foreshadowed by the results of the 2006 Dubbo study, which showed a connection between the apparent severity of the initial infection and the later development of ME. So, the worse/more fatigued you initially feel from the "trigger"/initiation of interferon...
  11. Forbin

    Hematological and psychophysiological correlates of anomalous information reception in mediums: A preliminary exploration, 2018, Beischel et al

    Jethro: "I read up here on these here castle ghosts, and all you gots to do is hold a séance and exorcise the rascals." Miss Jane: "But Jethro, you're not a medium!" Jethro (embarrassed): "I know. I'm a large."
  12. Forbin

    Suddenly feel completely well

    There was another thread where some people, myself included, talked about feeling better after waking up after only a few hours of sleep. I flew across county once and then slept only about 4 hours before I had to get up. When I woke up, I felt way better than usual. It lasted for 6-8 hours, but...
  13. Forbin

    Suddenly feel completely well

    It would seem like a good idea to get and store a blood sample from patients who suddenly feel well. These "well" samples could then be compared to either earlier blood samples taken while ill, or to future blood samples should they relapse. Comparing self-to-self seems like the ultimate...
  14. Forbin

    Parachute use to prevent death and major trauma when jumping from aircraft : randomized controlled trial

    This study is a thing of beauty - sort of like an elegant ocean liner - deploying a parachute - as it falls from the sky.
  15. Forbin

    Cases of Acute Flaccid Myelitis in Minnesota and other states

    It seems odd that AFM is peaking every other year (at least since 2014). When I searched for "biennial virus," the only two that seemed to show up were "Respiratory Syncytial Virus" and "Parainfluenza Virus," both of which are human respiratory viruses. It seems they think AFM may be caused...
  16. Forbin

    Is there a link between allergies and ME/CFS?

    Post onset, I had provocative skin testing done. I had some reactions to grasses, but, apparently, a fairly major reaction to corn. This seemed somewhat odd, since I never previously noticed any reaction from eating corn or products containing corn as an ingredient. Post onset, I did have a...
  17. Forbin

    Has anyone had any relief from vision issues. Laptop use currently hurting my brain!

    I think you're right and that your eyes are moving in anticipation of the screen scrolling. If you have dizziness/vestibular problems, trying to visually track objects can make you feel dizzy. When my dizziness was at its worst, I'd momentarily feel dizzy just from watching a car move across a...
  18. Forbin

    Increased risk of chronic fatigue syndrome following burn injuries, 2018, Tsai et al

    Sounds like they are talking about sunburn as opposed to heat injury. Although I used to get mild to moderate sunburns as a child, it stopped when I was a teenager and no longer had access to a pool. However, I went out on a friend's catamaran in my early twenties - one or two years before the...
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