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  1. Forbin

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    I'm wondering if there is any data on the prevalence of asymptomatic CCI or AAI. The Medscape article below says: It also says: The issue being that if some significant portion of the population has asymptomatic CCI or AII how can you tell if a positive finding on imaging is causing ME/CFS...
  2. Forbin

    Jen Brea: My ME is in remission

    I wonder if the NIH intramural clinical study attempts to rule out CCI. I assume this would require MRI/CT scans of this area of the head/neck.
  3. Forbin

    Jen Brea: My ME is in remission

    I'm curious about how this condition could be triggered (or perhaps "unmasked") by an infection. Jennifer has written that she believes her trigger was an infection.
  4. Forbin

    Stop Ignoring ME Video

    I missed this when it was first posted. Truly excellent work! :thumbup:
  5. Forbin

    Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study, 2019, Tsai et al

    I was diagnosed with scalp eczema a couple of years prior to ME. This seemed to morph into a diagnosis of scalp psoriasis about 10 years after the onset of ME. Fortunately it is intermittent and confined to the scalp. It seems that people who have psoriasis are more likely to have Crohn's...
  6. Forbin

    Acute psychological stress increases serum circulating cell-free mitochondrial DNA, 2019, Picard et al

    There was an article on this research in Scientific American last September: Brain’s Dumped DNA May Lead to Stress, Depression The article doesn't get into this, but could the biological stress caused by the immune system's reaction to mitochondrial DNA in the bloodstream wind up causing the...
  7. Forbin

    #MEAction: "Unseen: Black people living with ME"

    FWIW, I made the chart below from the results of Leonard Jason's 1999 study "A Community-Based Study of Chronic Fatigue Syndrome." It shows the prevalence rates that he found for various groups. The three vertical dots show the prevalence rate per 100,000 people surrounded above and below by...
  8. Forbin

    The Independent - What are the symptoms of ME and how is it treated? May 2019

    So, somewhere between "no one" and "all people"-1 then.
  9. Forbin

    Psychiatrist Peter White at the Royal Society of Medicine 2008 - Defining CFS/ME

    No doubt multiple sclerosis, with its multiple, varied and variable symptoms was declared psychological for the same reason, i.e. too many symptoms. Another triumph for inductive psychological diagnosis.
  10. Forbin

    More PACE trial data released

    I could be wrong, but I believe the Borg Scale is a measure of resistance... ;)
  11. Forbin

    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    Not to take the thread off track, but I came across this interesting 2016 article in Science about a doctor who's involved in research into the poorly understood, often deadly illness known as Castleman disease. He has a very personal reason for doing so, as he has it himself. Although he's not...
  12. Forbin

    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    I was just thinking that the more numerous and varied the diseases that the nanoneedle detects, the more difficult it's going to be figure out the common denominator, and it would increase the likelihood that the denominator is a common consequence of most diseases. Which makes me wonder if it...
  13. Forbin

    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    I'm thinking that Gulf War Syndrome (GWS) might be a really important disease to test the nano-needle against. Nancy Klimas says that the GWS and MECFS are symptomatically indistinguishable. I don't know if that extends to objective measures of dysfunction, like a 2-day CPET, but it might...
  14. Forbin

    Multidisciplinary Biopsychosocial Program for Chronic Musculoskeletal Pain at the Dead Sea, 2019, Dramsdahl et al

    This kind of reminds of the way tuberculosis was treated in the late 19th and early 20th century. In the western United States, numerous sanitariums / sanatoriums were established as fairly posh resorts where wealthy TB patients could go to get fresh air, away from the "sooty" and crowded...
  15. Forbin

    Mold as a possible cause of CFS

    About three months prior to onset, I had a fairly massive exposure to mold. I was assigned to move some huge bolts of fabric in a beachfront warehouse attic space. They smelled of mold and the air was thick with "dust" (mold spores?) when I moved them. I remember thinking that this was probably...
  16. Forbin

    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    I suspect that the "media blitz" is probably the result of the paper being published in PNAS. It's the second most cited journal in the world (after Nature) and health & science reporters no doubt search each issue closely looking for something of general interest to write about. ME/CFS, with...
  17. Forbin

    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    Even more to the point, can we be sure that the patient PBMC's weren't sent a newsletter telling them how to respond to the test? ;)
  18. Forbin

    Dr. Ron Davis of Stanford - Research Update - Drug Screening. Video from Emerge Symposium March 2019, Australia

    From the chart, the ME/CFS samples seem OK at first, but, after half an hour to an hour they "give up" quite abruptly (the nearly vertical red lines) as though the cells have run out of something (ATP?).
  19. Forbin

    Dr. Ron Davis of Stanford - Research Update - Drug Screening. Video from Emerge Symposium March 2019, Australia

    FWIW, what I think is going on in this chart is that sodium has been added to the samples prior to any of the measurements shown. Sodium is a conductor, so it has lowered the resistance to the flow of electricity (the impedance) in the serum to the level of about "1" in all the samples. As time...
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