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What 'neuroscience' is this then? If this 'faulty alarm signal' / 'fight or flight' loop is your preferred hypothesis, that's fine. But what neuroscience backs up this explanation? And why wasn't this claim challenged?

Yes, you are right. I missed that.

Possibly. I will consider that after discussions here. I could be convinced this is all fully legit now, but there are many peculiarities.

Ok. I shouldn't have posted last night without explaining why the paper struck me as potentially problematic. It was getting late and I needed to come off the laptop. I have many questions and would not claim that this paper was potentially not authentic without first doing a bit of digging...

I believe this is a fake/AI paper. The list of affiliations is highly suspect. None of the author profiles online matches the content of the paper.

Are these in any particular order?

Reminds me of something..... (Not one mention of ME/CFS in the entire paper by the way.)

https://meassociation.org.uk/2026/05/new-provider-announced-for-kent-and-medway-me-cfs-and-long-covid-service/ MEA reporting that Cora Health, a private equity-backed company that has a number of NHS contracts, has won this award. https://www.nhsforsale.info/private-providers/cora-health/

This is also probably one of the primary reasons why we know so little about ME/CFS.

(opens in new tab) Interleukin 6 as a Treatment Target for Depression Visual Abstract. Importance Interleukin 6 (IL-6), a keystone inflammatory cytokine, is a credible mechanistic candidate for causing depression. However, randomized clinical trials testing its treatment potential remain...

I have researched vision issues a lot because they are some of my most disabling symptoms, although this is largely due to my having visual snow syndrome on top of ME. The optic nerve is just one part of the visual pathway — the other parts are the eyes (the retina, in particular), and...

I'm also a male with PoTS but it's just a well known fact that this is a highly female predominant condition. The figures cited are usually somewhere in the region of 75–85% female predominance, although some studies are higher than that (like this one).

:emoji_warning: Maes Alert :emoji_warning:

Are we to assume that the rest of the paper is not affected by this correction?

Just a minor correction for Bogus Bruce P: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1832958/full "In the published article, there was an error. In section Materials and Methods, Patients, it was indicated that a total of 144 individuals were enrolled in the...

Actually, that was the other Kell paper posted this moring. That has 439 references.

I noticed the insane amount of references. Douglas and co seem to publish a lot (in any old journal), and I'm not convinced it's of the highest quality.

Has someone got a screenshot of Neil's comment?

Yes, I think parts of Unrest are certainly dramatized. In fact Jen Brea in my opinion does not look like a typical ME/CFS patient. The fits and collapses are not representative of my experience. I suppose we only saw the 'highlights' (or 'lowlights' perhaps). Most of us are much more boring than...

I feel like this could work / be helpful, but only if the HCPs were in that role-play scenario for a whole day or even several days — not just a few minutes like if you wanted to simulate blindness.