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I was just learning about them and exploring other ways that NK cells could be involved given things like the daratumumab experiments and just that they seem to crop up a lot. I don’t think we’ve seen anything *wrong* with them anywhere but that doesn’t mean they couldn’t be part of the story in...

I can’t speak to the validity of the findings but that there’s an attempt to try to differentiate fatigue from PEM and just measure these things in people’s homes seems worthy. Maybe looking at people in PEM would yield clearer results? They seem to touch on this and other limitations They...

Actually some nice understanding shown in parts. I can’t quite get my head around their definitions but they tried a few ways of grouping people, which seems interesting. There seems to be a better understanding of there being a difference between fatigue and PEM than we see from many though

There’s been lots of people talking of things like microclots in LC but has there really been much reliable evidence? My understanding was it was very much up in the air with not much understanding of if it’s relevant in particular groups let alone a general underlying problem. And I’m even less...

This is where I think some of the PrecisionLife results were not presented as well as they could. They talked about heterogeneity and complexity a bit too much IMHO sometimes giving the impression of different groups or fragmenting the cohort. My interpretation or reading of the clusters of...

Finally got it together to sign up. I’ll never be able to be as involved as some on here are (and I’m always impressed with what they achieve) but hope I can contribute something. And yes not all research teams are as great as those who regularly contribute here or have been involved with...

Really good webinar, Chris communicating well and being inspiring as ever and always great to hear @Andy Thanks to all involved. I’m always impressed with what Sonya has brought to AfME and the political and organisational stuff it takes behind the scenes. Agree that the sooner we can get...

Here you go, should allow easy access to the genecard for each gene and the genehancer info, ensembl info, locuszoom etc for the regulatory elements https://astrazenecapromoters.pages.dev/ So here’s all the decodeme identified snps in the area whch pass the significance threshold and could be...

DecodeME LocusZoom for BTN2A1 and genecard (this is the one in an area of a hit, you can see how it could be a promotors/enhancers of this gene like this one shown on Genehancer and LocusZoom although there seems to be lots of uncertainty and the SNPs could modify genes a long way away) I’ll...

Having experienced both they are very different. This is of course subjective and I can see why some externally would see similar elements and even diagnose both. But to me it says a lot about how poorly we understand both. And I wouldn’t be surprised to find some commonality or crossovers in...

The webinar looks to have been posted

For people interested it’s worth looking at some of Oxford Nanopore’s blurb, one of the things I’m interested in beyond the core sequencing is methylation. There’s a lot of info linked from here https://nanoporetech.com/platform Including an overview of the technology...

I’m severe so the idea of these tests always sound completely alien to me. However before being ill I would run, push myself, have a high heart rate and after it would drop and I’d feel tired but also good. Since being ill even small increases, well below 90 let alone maximal, either have or are...

I had wondered if these sperm related genes cropping up in different places were related to generalised chemoreceptors but maybe there’s something else going on with cell trafficking or transport?

If you look at the genecards page for a gene it usually shows a bunch of papers related to it too. As well as info on expression etc. They’ve recently changed the layout and it seems easier to navigate. But there’s a lot of info there

It’s certainly a very leading selection that they looked at so that doesn’t tell us much beyond their priors/theories. I’m not sure if it’s more interesting that they found some raised, some not or that in the 15 years since we haven’t, AFAIK, heard much in the way of replication?

Genecards say “The protein is localized to the membrane and Golgi apparatus, placing it in compartments that support intracellular trafficking and membrane-associated processes” And it seems to crop up mitosis in the RNAi phenotypes section in screens for Increased G2M DNA content and Increased...

Things they measured and my assumptions at what some are, please correct me as needed! Metabolites ASIC3 genecard P2X4 genecard and a little spike on DecodeME’s locuszoom (now known as P2RX4) P2X5 genecard TRPV1 genecard Adrenergic receptors α-2A (assuming this is ADRA2A) genecard β-1...

The links between occurrence, symptoms, hormones and sex differences are really interesting. And wow @Mij that sounds like quite an experience! I only experienced migraines since getting me/cfs, onset and worsening of which included periods of severe headaches and nausea but only had a period...

Nothing much going on in DecodeME LocusZoom for SCN2A sadly