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I tried lots of ways to more objectively do so, with various attempts measuring or tracking things. But an element of empiricism seems to work best. Time, experience and listening and learning from what your senses tell you. But it’s an ongoing process and there’s no right answer. What each of...

Who says motivations, in economics or otherwise, are rational? We are all immensely good at fooling ourselves.

Here’s all the threads tagged with dopamine And all threads with aripiprazole or abilify. I also wonder about non-direct modifiers? Things like Naltrexone could impact dopamine, well, probably does, but I guess if we get into indirect pathways it gets confusing.

Here’s what I”ve got so far. Hopefully mostly accurate. We need a wiki with multiple people able to edit really.. D2 Receptor Antagonists First generation antipsychotics Haloperidol, Chlorpromazine, Fluphenazine, Perphenazine, Thioridazine Second generation antipsychotics (also block 5-HT2A)...

I’ve been thinking and reading more about dopamine. Partially because of interest in PD but also now in relation to eccentric medium spiny neurons aka eccentric spiny projection neurons (which have both D1 and D2 receptors). And from what I’ve read D1 generally excites the post-synaptic neuron...

I wonder if these and other dopamine modifying substances will get more attention or thoughts around potential mechanisms with some of the recent genetic findings implicating eMSNs/eSPNs.

It seems that elevated prolactin is unlikely to be our problem (see https://en.wikipedia.org/wiki/Hyperprolactinaemia) but the way in which it and dopamine interact with effects on GABA in another of these finely balanced and regulated systems does seem enticing somehow. If there were a problem...

And on the receptor A bit more from the dedicated Wikipedia page

Some other bits from reading From the Wikipedia page for prolactin A lot to unpick and things may not be a clear single directional effect, but the relationship to dopamine and variation with sleep/wake and menstrual cycles aa well as changes in pregnancy given the reports we have on...

Thanks @ScoutB that’s really useful. DecodeME Locuszoom for DRD2 which I guess you could say maybe shows a little hump in the area but nothing significant. And not even a blip on DRD1, 3 or 4.

Thanks for letting us know @Andy and nice suggestion @Yann04 :)

Great, thank you so much!

Haven’t read through all this yet but it seems interesting. Some initial questions/thoughts. What would this mean for other drugs interacting with 5-HT 1A serotonin receptors? There seems to be a lot. And many seem prescribed things like SSRIs or other antidepressants, with mixed results. Even...

Thanks for explaining @mariovitali an interesting approach! If you’ve written more on this anywhere please do share any links. On the topic of this thread IMHO the solution in the healthcare industry is for those in it to provide better support. Then fewer people will turn to unsuitable...

No significant signs on LocusZoom PRL PRLR HTR1A

Thread on that paper here btw https://s4me.info/threads/transfer-of-igg-from-long-covid-patients-induces-symptomology-in-mice-2026-chen-et-al.38759/ Others can probably etter chime in on what studies have haven’t been done better but I don’t think there’s has. And there’s few studies in and out...

A different take on the immune system reaction. Also see this write up in Arstechnica When they’re being eaten, bean plants release chemicals that draw in parasitic wasps.

A plant immune receptor mediates tritrophic interactions by linking caterpillar detection to predator recruitment Abstract Plants deploy direct and indirect defenses in response to insect herbivory. The specific antiherbivore responses involve cell surface immune receptors that recognize...

It’s probably difficult as I’m not sure its home vs a place like this that is the discriminating factor, but the approach, attitude of carers and environment provided. Not sure how you can control for that. Well put @Utsikt

Adding this from another thread. It’s a YouTube channel from the guy who was involved in discovering the vault, a part of the cell I haven’t seen discussed and that we don’t know what it does! I’ve been listening to his videos today and they cover a lot more about cell biology, nanotechnology...