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Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity Pujantell, Maria; Altfeld, Marcus Abstract The immune system protects us from pathogens, such as viruses. Antiviral immune mechanisms aim to limit viral replication, and must maintain immunological...

That’s a good point @Utsikt talking about neurological conditions and some of these topics could worry people. The way I see it we can have these genes or pathways involved or implicated by them involved in ME/CFS without any need for ongoing tissue damage or a degenerative condition. It’s a...

HTT and spiny neurons seems maybe worthy of more investigation, they seem very interrelated. It’s not a gene I think we spent much time on but was one of the DecodeME candidates even if a bit below the threshold. LocusZoom for HTT.

First bash at working with the brain tissue specific data and the DecodeME geneset is here https://dev.decodemebrainregions.pages.dev/ Using the same pipeline I did before but with different preprocessing step from that used with GTEx to get the tissue expression data. I can't be sure that my...

It’s all been happen hasn’t it! And welcome to the forum @James Cox great to have you here! I think we’re all looking forward to seeing what any research you’re involved in shows up. The only tissue expression stuff I’ve looked at so far has been very broad using GTEx data and looking at...

Ah gamma delta T cells. Got it thanks! So many acronyms.

What are gdT cells?

Really interesting, thanks for this @ME/CFS Science Blog A great overview and explanation woth some really interesting ideas. I Also hadn’t twigged the use of a special dataset looking more narrowly at tissue expression in the brain. The Brain Atlas looks very useful and I wonder if I can try...

But they need not even have a direct influence, there could be an intermediary right? Some other signalling molecule for instance, interferon. I really do think there could be something here that helps fill in part of the picture, one of a few jigsaw pieces that will fit together and show us...

Yes, good question. Here’s the locus https://my.locuszoom.org/gwas/894183/region/?chrom=17&start=10402663&end=12402663 And the genecard https://www.genecards.org/cgi-bin/carddisp.pl?gene=SHISA6 It looks like there’s an enhancer hit, although you need to lower the threshold a bit, seems...

I need to catch up with this but it looks very interesting. This is fantastic work @paolo Really hope it gets the attention it deserves and hope the right people are looking. Also really gratifying to have some of the things that seemed to be indicated from my experiments and lines of thought...

I’m late to this and haven’t been as active on the forum recently but am so incredibly pleased to hear this. It’s great news. I’m thankful for everyone who has been working behind the scenes to achieve this. It feels like some of the lobbying individuals have dine has helped too so I support any...

Given its not an educational thing but a fundraising thing, we should probably look at it in that respect and on that front I think it says a lot about Sonya that she’s been able to get this.

There’s been an interesting webinar hosted by Altmetric today, called “The Online Life of Retracted Science: the news cycle, social media and journalistic responsibilities” Here’s a webpage with all the posts from a live thread summarising what was discussed. Full video and slides will be...

Ah, interesting. I wondered about different NK cell subtype populations but hadn’t twigged that. There seems to be some discussion of more long lived NK cells in some papers, particularly in certain tissues or in these ‘memory’ NK cells? I’m not sure how that compares to other long lived immune...

While looking at CD38 involvement I also came across this paper which seems to indicate expression of CD38 is similar on both but bright have more of a regulatory role which is influenced by CD38 pathways. I can’t access it unfortunately but from the abstract it looks like it could also be...

Thanks. Oh well, guess we can’t have everything. It sounds like it’ll all still be good useful info.

Also this from the Introduction Not sure what it all means! Wiser minds may want to chip in. But I found the different types of NK cells and the tissues they lurk in interesting. There’s also some papers on their potential role in neurological conditions.

Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus Abstract Summary Natural killer (NK) cells belong to the innate immune system but can also affect adaptive immune reactions. This immune regulatory function is often ascribed to the...

Nice work introducing them @ryanc97 will be interesting to see what they turn up. Do you know if he/they are also looking at NK cells themselves? We’ve talked before about the idea of memory in the innate immune system as well as the adaptive, there seems to be increasing discussion of memory...