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Sorry the twelfth mistake screws up the Bonferroni correction so I can only offer (virtual) rich tea biscuits.

But maybe the micro-dosing potentiated the power. You might end up blowing your mind by self-dosing just one teeny time.

Now girls and boys, who can spot the eleven mistakes in this protocol? Jaffa cakes will be distributed to all those providing the correct answers by Thursday (or at least virtual Jaffa cakes). I love the micro-dosing, as would Samuel Hahnemann stroking his harp in heaven.

And being old is a ten times commoner cause of widespread pain, I can assure him. There is now only one position I can lie in at night for more than ten minutes.

I am glad they made them a colour that no other capsule comes in.

Yes, at least officially. NICE is the gold standard in practical terms in this respect. But if health care workers are not up to speed on details they may misapply the terms and they may misapply them differently.

Yes, but as Peter Barry pointed out at the Round Table, none of this was material since these studies were included. The evidence was further downgraded in relation to recruitment but this actually made no difference to NICE's conclusions. Things were weak enough anyway to say treatment could...

In this particular case I agree. But there is a spectrum. Another quote I remember from an advisory board where the phase 3 rituximab data were revealed was from a US rheumatologist who openly said that US physicians would not be interested because it only required one infusion a year (and they...

That is true but more and more I see that what has happened in ME maybe should be happening on a much wider scale in areas where the problem is not unethical or unscientific action but just a lack of motivation to solve the problems that would really matter for patients. I remember the occasion...

Yes, again I agree this misses the point. Being a scientist is just being someone who is interested in solving a problem and in thinking clearly. 'Lay' members on ethics committees and such like have been around for decades and done important work. The internet has probably contributed in...

Nor I. Some members of online communities pushed this angle but it was not what made the difference to NICE and not what dominated the discussion on this forum.

I can access it via UCL. Unfortunately the paper seems to be an extended snowstorm of poor evidence (which is what to expect from this journal by the way). I note the following statement: These findings, and the observation that autoantibodies targeting therapies, including immunoadsorption and...

I had never heard of him until I joined this forum and saw his Tweets. I suspect the vast majority of physicians have never heard of him. Amongst BPS enthusiasts he may be well enough known, but he may just be someone who Tweets support for the big showmen - I don't know.

I am not sure that anything unnoticed is being reported here. Without appearing to be biased I would note that this is a review published in a journal nobody has ever heard of from some people in Morocco. We have known that platelets are involved in signalling at least since I took an interest...

I am not aware that there is any knowledge to share. I have heard reports like this from social contacts. Carson is clearly very good at playing the listening role. But several months later the emptiness and hypocrisy of it tend to dawn. For those who were going to get better he will score well...

How did Eric Topol suddenly become a leading expert of Long Covid since nobody knows anything about it? Or Iwasaki or Putrino for that matter? And what is all this research on ME to build on that Vogel is talking about? It is good to see the BPS approach being ridiculed but I don't think it...

I am afraid I never took much interest in ferritin. It mostly seemed to be a red herring, other than in the context of haemochromatosis. Other things more directly reflect inflammation.

I think this paper IS disinformation. The whole tone is much too presumptive that we know something is going on when the reality is that a few groups have reported non-replicated findings. I see no difference between this and telling people they have craniocervical instability or EDS or...

This seems to be an interesting finding. However, I see that the subjects were overweight or obese. Metformin is used in people who are overweight with diabetes to modify sugar metabolism if I remember rightly. If it had a beneficial effect on a pre-diabetic state that made people feel generally...

It could but in the long term many people eventually get a loss of immune defences - maybe 5-10% will develop a condition that lowers resistance, such as diabetes. So we would expect 5-10% of PWME to eventually suffer from overt infection with the hidden agent. An analogy would be herpes...