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Just to say here, that in a meeting held by the TAL Research group (Michal Tal), I gave specific targets of interest related to Lyme disease. Interestingly, Lyme disease disrupts phospholipids and also uses Heparan Sulfate (a Glycosaminoglycan) to attach to the host. Both of these may be key...

Let's see again efferocytosis, taking also into account the post about MerTK (previous post). Here is how things are currently appear to be. In red is what we know from studies on ME/CFS :

So we may also have evidence of impaired MerTK signalling in COVID19, I am wondering if this could be also applicable to ME/CFS and LongCOVID. Study from Stanford University . Link : https://pmc.ncbi.nlm.nih.gov/articles/PMC9238057/

I went through the thread quickly and just wanted to share that one of the things I found during analysing my symptoms and interventions through machine learning, one of the key factors appeared to be P450 inhibitors. Source ...

@DMissa and @TamaraRC please have a look at this. Extensive content on the role of Phosphatidylserine (PS) and phospholipids. Also mentions efferocytosis.

Etheresia Pretorius,Chantelle Venter,Jean M. Nunes,Alain R. Thierry,Douglas B. Kell Abstract Hypercoagulability, immunothrombosis, and protein misfolding are deeply interconnected processes that converge on cell membranes as central orchestrators of thrombo-inflammation. In health, membrane...

A quick update : In a 2-hour meeting I was really honoured to present my work to members of the TAL Group of MIT and also learn about their research efforts : https://talresearchgroup.mit.edu/team The TAL Research Group also runs MAESTRO, which is the largest clinical study in MIT history ...

It's been quite some time since I posted on my blog but the proposed target deserves it. As always, this is not a post which suggests any kind of supplementation. I propose the investigation of Fucoidan for the amelioration of symptoms of ME/CFS and LongCOVID. I also propose that impaired...

Disclaimer : The following information is NOT a suggestion to try Sulodexide. Please, please talk to your doctor before trying any supplement or medication Sulodexide is a medication containing Heparan sulfate (80%) and Dermatan sulfate (20%). I propose that research should be targeted to HS...

Thank you @Hutan I really appreciate your approach. As you know I am not a medical professional and it would be a shame for me to generate a hypothesis without prior knowledge. However in a nutshell this could be one hypothesis : **Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)...

The fact that you do not understand how I've gotten to the answers is irrelevant, given the fact that whatever methods were used it *appears* to be working (note the term "appears" - more on this below) . This has been answered previously in this thread. My approach was to identify associations...

In another coincidence (?) efferocytosis is very active during pregnancy. using AI but fairly sure this is correct : This is why PEM is delayed (my hypothesis). Unbeknownst to me, in 2017 I did not know about efferocytosis but I got very close (used Phagocytosis instead). Note that I...

I am posting this message mainly as a future reference. I posted many times previously about being happy that our thoughts are being recorded in this forum. With full responsibility of what I am posting here, I hypothesise that the beginning of the end of ME/CFS is here, for the majority of...

Has anyone noticed the "antiphospholipid"part? What do we find consistently in MECFS patients to be low?

How about identical twin studies where one has MECFS and the other doesn't?

I wanted to make sure everyone sees the following again

@jnmaciuch so a "coherent biological story" is the conversation about B Cells and lipids ? So maybe we are looking at a Single Point Of Failure (SPOF) in ME/CFS am I correct (so we do not care about ER Stress, impaired N-glycans, LXR downregulation, etc etc) ? If this is what you are implying...

Sure, I understand this but then again we have additional evidence -given the GWAS- that certain defects in ER-phagy may be at play and since the Endoplasmic Reticulum (ER) is the site of lipid metabolism (am I right ?) it is possible that a combination of defects (ER-phagy, vesicle trafficking...

Please find my responses inline, below I will have to go through my notes however I made sure that there is a written track of everything via documents shared, e-mails, social media posts (mainly Twitter/X) and a blog which can be found here : https://algogenomics.blogspot.com/ I am glad...

I do not understand why we mention lipid abnormalities for B Cells specifically. Does this mean that because B Cell-derived LCLs were used , lipid abnormalities in MECFS patients should be only considered for these kind of cells ? Don't we have evidence of lipid abnormalities and specifically...